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9-Nitro-20S-camptothecin

9-Nitro-20S-camptothecin

Product ID C0156
Cas No. 91421-42-0
Purity ≥98%
Product Unit SizeCostQuantityStock
25 mg $144.60 In stock
50 mg $234.70 In stock
100 mg $377.90 In stock
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Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

9-nitro-20S-Camptothecin is a camptothecin derivative. Camptothecin is a quinolone alkaloid precursor of irinotecan; it is originally found in Camptotheca. Camptothecin exhibits anticancer chemotherapeutic activity, inhibiting topoisomerase I and inducing double-stranded DNA breaks. Camptothecin is extremely cytotoxic and only its derivatives are clinically used as chemotherapeutics.

Product Info

Cas No.

91421-42-0

Purity

≥98%

Formula

C20H15N3O6

Formula Wt.

393.35

Chemical Name

9-Nitro-20(S)-Camptothecin

IUPAC Name

(19S)-19-ethyl-19-hydroxy-8-nitro-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione

Synonym

Rubitecan, 9-nitrocamptothecin, 9-nitro-CPT

Melting Point

182-186°C

Appearance

Orange Crystalline Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

C0156 MSDS PDF

Info Sheet

C0156 Info Sheet PDF

References

Rodríguez-Berna G, Mangas-Sanjuán V, Gonzalez-Alvarez M, et al. A promising camptothecin derivative: Semisynthesis, antitumor activity and intestinal permeability. Eur J Med Chem. 2014 Jun 25;83C:366-373. PMID: 24980118.

Berniak K, Rybak P, Bernas T, et al. Relationship between DNA damage response, initiated by camptothecin or oxidative stress, and DNA replication, analyzed by quantitative 3D image analysis. Cytometry A. 2013 Jul 11. [Epub ahead of print]. PMID: 23846844.

Redinbo MR, Stewart L, Kuhn P, et al. Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA. Science. 1998 Mar 6;279(5356):1504-13. PMID: 9488644.

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