LKT Labs

Biochemicals for Life Science Research

Epothilone D

Epothilone D

Product ID E6356
Cas No. 189453-10-9
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $112.20 In stock
5 mg $245.30 In stock
10 mg $428.70 In stock
25 mg $918.80 In stock
Bulk Quote

Quicklinks

Description

Epothilone is an anticancer chemotherapeutic that acts as an anti-mitotic compound; it binds the taxane pocket of β-tubulin, using side chains to induce formation of a short helix and preventing microtubule depolymerization. Epothilone displays activity against lung cancer and prostate cancer in clinical trials and may show benefit in treatment of neurodegenerative diseases such as Alzheimer’s disease. Typically, the degree of chemotherapeutic activity of the three epothilone subtypes follows the alphabet, where Epo A> Epo B> Epo D.

Product Info

Cas No.

189453-10-9
Purity

≥98%
Formula

C27H41NO5S
Formula Wt.

491.68
Chemical Name

(4S,7R,8S,9S,13Z,16S)-4,8-dihydroxy-5,5,7,9,13-pentamethyl-16-[(E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-1-oxacyclohexadec-13-ene-2,6-dione
IUPAC Name

(4S,7R,8S,9S,13Z,16S)-4,8-dihydroxy-5,5,7,9, 13-pentamethyl-16-[(E)-1-(2-methyl-1, 3-thiazol-4-yl)prop-1-en-2-yl]-1-oxacyclohexadec-13-ene-2,6-dione
Synonym

Desoxyepothilone b
Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

E6356 MSDS PDF
Info Sheet

E6356 Info Sheet PDF

References

Prota AE, Bargsten K, Zurwerra D, et al. Molecular mechanism of action of microtubule-stabilizing anticancer agents. Science. 2013 Feb 1;339(6119):587-90. PMID: 23287720.

Entwistle RA, Rizk RS, Cheng DM, et al. Differentiating between models of epothilone binding to microtubules using tubulin mutagenesis, cytotoxicity, and molecular modeling. ChemMedChem. 2012 Sep;7(9):1580-6. PMID: 22807375.

Edelman MJ, Shvartsbeyn M. Epothilones in development for non--small-cell lung cancer: novel anti-tubulin agents with the potential to overcome taxane resistance. Clin Lung Cancer. 2012 May;13(3):171-80. PMID: 22133291

Kelly WK. Epothilones in prostate cancer. Urol Oncol. 2011 Jul-Aug;29(4):358-65. PMID: 19914096.

Lee JJ, Kelly WK. Epothilones: tubulin polymerization as a novel target for prostate cancer therapy. Nat Clin Pract Oncol. 2009 Feb;6(2):85-92. PMID: 19048010.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A7618

    Atenolol

    β1-adrenergic antagonist.

    ≥98%
  • C5680

    Coumestrol

    Phytoestrogen found in various plant sources; E...

    ≥97%
  • F4581

    5-Fluorocytosine

    Synthetic antifungal.

    ≥98%
  • S8007

    Substance P (1-7)

    Endogenous tachykinin peptide, involved in infl...

    ≥95%
  • F4482

    Fluvastatin Sodium

    Statin; HMG-CoA reductase inhibitor, potential ...

    ≥98%
  • T0004

    T2 toxin Triol

    Trichothecene mycotoxin produced by Fusarium; p...

    ≥97%, TLC
  • C0247

    Calcineurin Autoinhibitory Peptide

    Peptide; calcineurin inhibitor.

    ≥95%
  • T3134

    Thiostrepton

    Thiazole; proteasome inhibitor, protein translo...

    ≥97%, HPLC
  • S5869

    Sorafenib Tosylate

    c-Raf, RET, VEGFR1 inhibitor, potential HMT inh...

    ≥99%
  • P3592

    Pixantrone Dimaleate

    Aza-anthracenedione, DNA intercalator; topoisom...

    ≥98%
  • C6982

    Crustacean Cardioactive Peptide

    Neuropeptide hormone found in arthropods.

    ≥95%
  • C9200

    CX-6258

    Pim kinase inhibitor.

    ≥98%
  • N8604

    NVP-BGT226

    PI3K and mTOR inhibitor.

    ≥98%
  • C2942

    Mechlorethamine Hydrochloride

    Nitrogen mustard, DNA alkylator.

    ≥98%
  • E846182

    Everolimus EP Impurity E

    Impurity of everolimus

    ≥80%
  • P6800

    Pravastatin Lactone

    Statin; HMG-CoA reductase inhibitor.

    ≥98%
  • C1718

    Cepharanthine, 95%

    Alkaloid found in Stephania.

    ≥95%
  • A5234

    Amisulpride

    5-HT7 and D2/3 antagonist.

    ≥98%
  • A5283

    [Sar1]-Angiotensin II

    Peptide, derivative of AT II, involved in vasoc...

    ≥95%
  • C5592

    CNX-774

    BTK inhibitor.

    ≥98%