• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Iberin

Iberin

Product ID I0416
Cas No. 505-44-2
Purity ≥97%
Product Unit SizeCostQuantityStock
10 mg $228.30 In stock
25 mg $537.70 In stock
50 mg $857.20 In stock
100 mg $1,505.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Iberin is an isothiocyanate (ITC) and sulforaphane homolog that exhibits antioxidative and anticancer chemotherapeutic activity. Like other ITCs, iberin may display chemopreventive potential by inducing phase II enzymes. In vitro, iberin induces Nrf2 nuclear translocation and increases levels of heme oxygenase-1 and glutamylcysteine synthetase, both potentially related to alterations in ERK signaling. Iberin also increases expression of antioxidative enzymes thioredoxin reductase 1 and glutathione peroxidase 2 in cellular models. In cancer cells, iberin induces p21 expression, decreases expression of cyclin-dependent kinases (CDKs) 2, 4, and 6, and increases caspase activity, resulting in apoptosis.

Product Info

Cas No.

505-44-2

Purity

≥97%

Formula

C5H9NOS2

Formula Wt.

163.26

Chemical Name

1-Isothiocyanato-3-(methylsufinyl) propane

IUPAC Name

1-isothiocyanato-3-methylsulfinylpropane

Synonym

3-Methylsulfinylpropyl isothiocyanate, 3-(Methylsulfinyl)-propyl isothiocyanate

Solubility

Ethanol. DMSO to 11 mg/mL. DMF to 16 mg/mL.

Appearance

Slight yellowish liquid

Shipping and Storage

Store Temp

-80°C

Ship Temp

Ambient

Downloads

MSDS

I0416 MSDS PDF

Info Sheet

I0416 Info Sheet PDF

References

Ernst IM, Palani K, Esatbeyoglu T, et al. Synthesis and Nrf2-inducing activity of the isothiocyanates iberverin, iberin and cheirolin. Pharmacol Res. 2013 Apr;70(1):155-62. PMID: 23403058.

Barrera LN, Cassidy A, Wang W, et al. TrxR1 and GPx2 are potently induced by isothiocyanates and selenium, and mutually cooperate to protect Caco-2 cells against free radical-mediated cell death. Biochim Biophys Acta. 2012 Oct;1823(10):1914-24. PMID: 22820176.

Traka MH, Chambers KF, Lund EK, et al. Involvement of KLF4 in sulforaphane- and iberin-mediated induction of p21(waf1/cip1). Nutr Cancer. 2009;61(1):137-45. PMID: 19116884.

Jadhav U, Ezhilarasan R, Vaughn SF, et al. Iberin induces cell cycle arrest and apoptosis in human neuroblastoma cells. Int J Mol Med. 2007 Mar;19(3):353-61. PMID: 17273780.

Jakobsen TH, Bragason SK, Phipps RK, et al. Food as a source for quorum sensing inhibitors: iberin frmo horseradish revealed as a quorum sensing inhibitor of Pseudomonas aeruginosa. Appl Environ Microbiol. 2012 Apr;78(7):2410-2421. PMID: 22286987.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • T0109

    13-Acetyl-9-dihydrobaccatin-III

    Found in Taxus, starting material for synthesis...

    ≥98%
  • R9632

    Recombinant Zika Virus NS1 Antigen

    Zika Virus antigen

  • L1628

    Ac-LEHD-pNa

    Caspase 9 substrate.

    ≥95%
  • P0109

    P7C3A20

    Fluorinated aminopropyl carbazole, neuroprotect...

    ≥94%
  • I4934

    Imipenem Monohydrate

    Carbapenem β-lactam; penicillin binding protei...

    ≥98%
  • E6245

    Eplerenone

    Mineralocorticoid antagonist.

    ≥99%
  • P8167

    Puromycin Aminonucleoside

    Purine nucleoside analog; DNA chain terminator,...

    ≥98%
  • D0033

    Daidzin

    Isoflavone, phytoestrogen, found in soy.

    ≥98%
  • M1687

    Mevinolin

    Statin, naturally produced by mushrooms; HMG-Co...

    ≥97%
  • M4200

    MK-0752

    γ-Secretase inhibitor.

    ≥98%
  • B3320

    Bifonazole

    Imidazole; HMG-CoA reductase, 14-α demethylase...

    ≥98%
  • P1952

    Penitrem A

    Neuroactive mycotoxin produced by Penicillum an...

    ≥97%
  • G3461

    Ginsenoside F2

    Triterpene saponin found in species of Panax.

    ≥98%
  • W0272

    S-(−)-Warfarin >99%ee

    Coumarin, more potent isomer; VKORC1 inhibitor....

    ≥99%
  • C0271

    Carfilzomib

    Epoxomicin analog; proteasome inhibitor.

    ≥98%
  • I5215

    Indolicidin

    Antimicrobial peptide.

    ≥95%
  • Y0002

    Y-320

    Phenylpyrazoleanilide; IL-17 production inhibit...

    ≥98%
  • G5322

    GNF-5

    Abl inhibitor.

    ≥99%
  • I6068

    Ipriflavone

    Synthetic isoflavone.

    ≥98%
  • K740640

    KSQ-4279

    USP1 inhibitor

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only