AS-604850 is an inhibitor of p110γ PI3K that exhibits anti-inflammatory and immunosuppressive activities. In animal models of experimental autoimmune encephalitis (EAE), AS-604850 decreases the number of leukocytes infiltrated into the CNS and ameliorates disease symptoms. AS-604850 also decreases chemotactic responses of eosinophils to platelet activating factor (PAF).
| Cas No. | 648449-76-7 |
|---|---|
| Purity | ≥98% |
| Formula | C11H5F2NO4S |
| Formula Wt. | 285.22 |
| Solubility | DMSO 57 mg/mL (199.84 mM) Ethanol 5 mg/mL (17.53 mM) Water Insoluble |
| Appearance | White Crystal Powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
|---|---|
| Info Sheet |
Li H, Park D, Abdul-Muneer PM, et al. PI3Kγ inhibition alleviates symptoms and increases axon number in experimental autoimmune encephalomyelitis mice. Neuroscience. 2013 Dec 3;253:89-99. PMID: 24012746.
Hasan AM, Mourtada-Maarabouni M, Hameed MS, et al. Phosphoinositide 3-kinase gamma mediates chemotactic responses of human eosinophils to platelet-activating factor. Int Immunopharmacol. 2010 Sep;10(9):1017-21. PMID: 20685403.
