Description
GDC-1971 is an inhibitor of SHP2. SHP2 is: Src homology region 2-containing protein tyrosine phosphatase-2. SHP2 impacts the activity of tyrosine kinase signaling and may be useful in controlling cancer growth.
Product Unit Size | Cost | Quantity | Stock |
---|
GDC-1971 is an inhibitor of SHP2. SHP2 is: Src homology region 2-containing protein tyrosine phosphatase-2. SHP2 impacts the activity of tyrosine kinase signaling and may be useful in controlling cancer growth.
Cas No. | 2377352-49-1 |
---|---|
Purity | ≥99% |
Formula | C25H26N8O |
Formula Wt. | 454.54 |
IUPAC Name | (3R)-1'-[3-(3,4-dihydro-2H-1,5-naphthyridin-1-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]spiro[3H-1-benzofuran-2,4'-piperidine]-3-amine |
Synonym | GDC1971 |
Appearance | Yellow powder |
Store Temp | -20°C |
---|---|
Ship Temp | Ambient |
Info Sheet |
---|
Punekar S, Velcheti V, Neel B, et al. The current state of the art and future trends in RAS-targeted cancer therapies. Nat Rev Clin Oncol. 2022 Oct;19(10):637-655. PMID: 36028717
Yuan X, Bu H, Zhou J, et al. Recent advances of SHP2 inhibitors in cancer therapy: current development and clinical application. J Med Chem. 2020 Oct 22;63(20):11368-11396. PMID: 32460492
Yusa S, Campbell K. Src homology region 2-containing protein tyrosine phosphatase-2 (SHP-2) can play a direct role in the inhibitory function of killer cell Ig-like receptors in human NK cells. J Immunol. 2003 May 1;170(9):4539-4547. PMID: 12707331
Xu Z, Guo C, Ye Q, et al. Endothelial deletion of SHP2 suppresses tumor angiogenesis and promotes vascular normalization. Nat Commun. 2021 Nov 2;12(1):6310. PMID: 34728626
Side chain attached to various taxanes.
Inhibitor of EGFR, HER2, and HER3.
Promotes Aβ clearance.
p110α PI3K and mTOR inhibitor.
Polyketide found in Setophoma.
Triterpene aglycone found in Radix Astragali; t...
pan-RAF inhibitor
PARP inhibitor.
NS3/4A serine protease inhibitor.
Endogenous APP peptide cleavage product, primar...
Mycotoxin produced by Aspergillus and Penicillu...
Endogenous peptide; FPRL1/2 agonist.
Impurity of diclofenac
Phenolic phytoalexin found in soy, grapes, and ...
Diterpene originally found in Rabdosia.
β-lactam; penicillin binding protein inhibitor...
Aspirin analog; hemoglobin chain cross-linker.<...
Flavanol originally found in Camilla (green tea...
Phytoalexin
Synthetic antioxidant that induces phase II enz...