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GDC-1971

Product ID G124088
Cas No. 2377352-49-1
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $95.00 In stock
5 mg $195.00 In stock
10 mg $325.00 In stock
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  • Product Info
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  • Description
  • Product Info
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  • References
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Description

GDC-1971 is an inhibitor of SHP2. SHP2 is: Src homology region 2-containing protein tyrosine phosphatase-2. SHP2 impacts the activity of tyrosine kinase signaling and may be useful in controlling cancer growth.

Product Info

Cas No.

2377352-49-1

Purity

≥99%

Formula

C25H26N8O

Formula Wt.

454.54

IUPAC Name

(3R)-1'-[3-(3,4-dihydro-2H-1,5-naphthyridin-1-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]spiro[3H-1-benzofuran-2,4'-piperidine]-3-amine

Synonym

GDC1971

Appearance

Yellow powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

Info Sheet

G124088 Info Sheet PDF

References

Punekar S, Velcheti V, Neel B, et al. The current state of the art and future trends in RAS-targeted cancer therapies. Nat Rev Clin Oncol. 2022 Oct;19(10):637-655. PMID: 36028717

Yuan X, Bu H, Zhou J, et al. Recent advances of SHP2 inhibitors in cancer therapy: current development and clinical application. J Med Chem. 2020 Oct 22;63(20):11368-11396. PMID: 32460492

Yusa S, Campbell K. Src homology region 2-containing protein tyrosine phosphatase-2 (SHP-2) can play a direct role in the inhibitory function of killer cell Ig-like receptors in human NK cells. J Immunol. 2003 May 1;170(9):4539-4547. PMID: 12707331

Xu Z, Guo C, Ye Q, et al. Endothelial deletion of SHP2 suppresses tumor angiogenesis and promotes vascular normalization. Nat Commun. 2021 Nov 2;12(1):6310. PMID: 34728626

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