• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Celecoxib

Celecoxib

Product ID C1644
Cas No. 169590-42-5
Purity ≥99%
Product Unit SizeCostQuantityStock
100 mg $118.40 In stock
500 mg $248.20 In stock
1 g $381.70 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Celecoxib is a non-steroidal anti-inflammatory drug (NSAID) that inhibits COX-2; it exhibits anti-inflammatory, analgesic, anticancer, and anti-metastatic activities. Celecoxib is clinically used to treat arthritis, acute pain, and ankylosing spondylitis. In hepatoma cells, celecoxib decreases the mitochondrial membrane potential, increases cytochrome c release, activates caspases 3 and 9, alters Bcl-2 and Bax levels, and induces apoptosis. In vitro, celecoxib inhibits release of IL-6, IL-1β, and MIP-1α, suppresses phosphorylation of JNK, and activates SIRT1. Additionally, this compound inhibits invasion and migration of nasopharyngeal carcinoma cells by decreasing activity of matrix metalloproteinases 2 and 9 (MMP2/9).

Product Info

Cas No.

169590-42-5

Purity

≥99%

Formula

C17H14F3N3O2S

Formula Wt.

381.37

Chemical Name

4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H- pyrazol-1-yl]benzenesulfonamide

IUPAC Name

4-[5-(4-methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide

Synonym

SC-58635, Celebrex

Melting Point

157-159°C

Solubility

Insoluble in water. Soluble in DMSO (200 mg/mL), ethanol (100 mg/mL).

Appearance

White-cream to white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

C1644 MSDS PDF

Info Sheet

C1644 Info Sheet PDF

References

Shao D, Kan M, Qiao P, et al. Celecoxib induces apoptosis via a mitochondria dependent pathway in the H22 mouse hepatoma cell line. Mol Med Rep. 2014 Oct;10(4):2093-8. PMID: 25109418.

Annamanedi M, Kalle AM. Celecoxib sensitizes Staphylococcus aureus to antibiotics in macrophages by modulating SIRT1. PLoS One. 2014 Jun 20;9(6):e99285. PMID: 24950067.

Li WW, Long GX, Liu DB, et al. Cyclooxygenase-2 inhibitor celecoxib suppresses invasion and migration of nasopharyngeal carcinoma cell lines through a decrease in matrix metalloproteinase-2 and -9 activity. Pharmazie. 2014 Feb;69(2):132-7. PMID: 24640603.

Shi S, Klotz U. Clinical use and pharmacological properties of selective COX-2 inhibitors. Eur J Clin Pharmacol. 2008 Mar;64(3):233-52. PMID: 17999057.

Subbaramaiah K, Howe LR, Bhardwaj P, et al. Obesity is associated with inflammation and elevated aromatase expression in the mouse mammary gland. Cancer Prev Res (Phila). 2011 Mar;4(3):329-346. PMID: 21372033.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • H9718

    2-Hydroxyflutamide

    Non-steroid; AR antagonist.

    ≥98%
  • B022691

    Baricitinib

    Selective and reversible JAK inhibitor.

    ≥99%
  • F4881

    Flumequine Sodium

    Fluoroquinolone; bacterial DNA gyrase inhibitor...

    ≥98%
  • P8169

    Purpurin

    Anthraquinone pigment found in madder root; O-a...

    ≥90%
  • M1879

    Metoprolol Tartrate

    β1-adrenergic antagonist.

    ≥98%
  • C0267

    Carnosol

    Diterpene compound originally found in Rosmarin...

    ≥98%
  • A4534

    Aliskiren Hemifumarate

    Renin inhibitor.

    ≥98%
  • D4873

    Meso-2,3-dimercaptosuccinic Acid

    Organosulfur, chelating agent.

    ≥98%
  • T1027

    2’-Benzoylcarbonyl D-seco-Taxol

    2’-Benzoylcarbonyl D-seco-Taxol is an impurit...

    ≥90%
  • N0114

    Nadifloxacin

    Fluoroquinolone; bacterial DNA gyrase inhibitor...

    ≥98%
  • A9708

    AZD-1208

    Pim-1 inhibitor.

    ≥98%
  • E7230

    Ethambutol Dihydrochloride

    Arabinosyl transferase inhibitor.

    ≥98%
  • T2402

    TG100-115

    p110δ and p110γ PI3K inhibitor.

    ≥98%
  • D1644

    Deltorphin I

    Opioid peptide; δOR agonist.

    ≥98%
  • T0106

    Xylosyltaxol

    Taxane found in species of Taxus; potential mic...

    ≥98%
  • N8561

    NVP-AEW541

    IGF-1R inhibitor.

    ≥98%
  • A044176

    Abemaciclib

    CDK inhibitor.

    ≥98%
  • A1616

    AEE-788

    Inhibitor of EGFR, HER2, VEGFR2, and FLT3.

    ≥98%
  • D3329

    7,8-Dihydroxyflavone Hydrate

    TrkB agonist.

    ≥99%
  • R8122

    Rufloxacin Hydrochloride

    Fluoroquinolone; topoisomerase IV and bacterial...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only