• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
NVP-AEW541

NVP-AEW541

Product ID N8561
Cas No. 475489-16-8
Purity ≥98%
Product Unit SizeCostQuantityStock
1mg $84.30 In stock
5 mg $168.70 In stock
25 mg $486.80 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

NVP-AEW541 is an inhibitor of IGF-1R that exhibits anticancer activity, inhibiting proliferation of pituitary tumor cells. This compound also increases sensitivity to other co-administered chemotherapeutics in pancreatic cancer cells, glioma cells, and prostate cancer cells.

Product Info

Cas No.

475489-16-8

Purity

≥98%

Formula

C27H29N5O

Formula Wt.

439.55

Chemical Name

7-[3-(azetidin-1-ylmethyl)cyclobutyl]-5-(3-phenylmethoxyphenyl)pyrrolo[2,3-d]pyrimidin-4-amine

IUPAC Name

7-[3-(azetidin-1-ylmethyl)cyclobutyl]-5-(3-phenylmethoxyphenyl)pyrrolo[2,3-d]pyrimidin-4-amine

Synonym

AEW-541

Solubility

DMSO 88 mg/mL (200.2 mM) Water Insoluble Ethanol Insoluble

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

N8561 MSDS PDF

Info Sheet

N8561 Info Sheet PDF

References

Rubinfeld H, Kammer A, Cohen O, et al. IGF1 induces cell proliferation in human pituitary tumors - Functional blockade of IGF1 receptor as a novel therapeutic approach in non-functioning tumors. Mol Cell Endocrinol. 2014 Apr 24;390(1-2):93-101. [Epub ahead of print]. PMID: 24769281.

Ioannou N, Seddon AM, Dalgleish A, et al. Treatment with a combination of the ErbB (HER) family blocker afatinib and the IGF-IR inhibitor, NVP-AEW541 induces synergistic growth inhibition of human pancreatic cancer cells. BMC Cancer. 2013 Jan 31;13:41. PMID: 23367880.

Isebaert SF, Swinnen JV, McBride WH, et al. Insulin-like growth factor-type 1 receptor inhibitor NVP-AEW541 enhances radiosensitivity of PTEN wild-type but not PTEN-deficient human prostate cancer cells. Int J Radiat Oncol Biol Phys. 2011 Sep 1;81(1):239-47. PMID: 21816290.

Premkumar DR, Jane EP, Pollack IF. Co-administration of NVP-AEW541 and dasatinib induces mitochondrial-mediated apoptosis through Bax activation in malignant human glioma cell lines. Int J Oncol. 2010 Sep;37(3):633-43. PMID: 20664932.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A3212

    3′-Azido-3′-deoxythymidine

    Nucleoside (thymidine) analog; DNA chain termin...

    ≥98%
  • N859610

    NVP-HDM201

    HDM2 inhibitor

    ≥99%
  • D5649

    Domperidone

    D2/3 antagonist, hERG K+ channel blocker.

    ≥98%
  • M4102

    MK-1775

    Wee1 inhibitor.

    ≥98%
  • L1869

    Lercanidipine Hydrochloride

    Calcium channel blocker.

    ≥98%
  • F8147

    Fulvestrant

    Induces ER degradation.

    ≥98%
  • S1606

    Secretin, porcine

    Endogenous peptide hormone, involved in water h...

    ≥95%
  • V174459

    Velpatasvir

    Inhibits NS5A

    ≥99%
  • P3210

    Picoplatin

    Pt-based DNA cross-linker.

    ≥98%
  • T1298

    TDZD-8

    GSK-3β inhibitor.

    ≥98%
  • A1369

    Adrenomedullin (13-52), human

    Endogenous peptide hormone, involved in cell gr...

    ≥95%
  • A0934

    Acivicin

    Glutamine analog; γ-glutamyl transferase, CTP ...

    ≥98%
  • B6902

    B-Raf IN 1

    B-Raf and c-Raf inhibitor.

    ≥98%
  • P2522

    S-(N-Phenylthiocarbamoyl)-glutathione

    Glutathione-ITC conjugate, antioxidant.

    ≥98%
  • P1955

    Pentagastrin

    Synthetic peptide, stimulates gastric acid secr...

    ≥95%
  • C4559

    Clomiphene Citrate

    Used for in vitro fertilization; FIASMA, SERM.<...

    ≥98%
  • E6994

    Erythromycin

    Macrolide; protein translation inhibitor, mamma...

    ≥94%
  • R2710

    Recombinant Multi-epitope Chimeric HCV Antigen

    Recombinant Multi-epitope Chimeric HCV antigen....

    ≥95%
  • M1677

    11-Methoxyyangonin

    Minor kavalactone originally found in Piper met...

    ≥98%
  • E5178

    Emtricitabine

    Nucleoside (cytidine) analog; RT and telomerase...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only