LKT Labs

Biochemicals for Life Science Research

Mefenamic Acid

Product ID M1622
Cas No. 61-68-7
Purity ≥98%
Product Unit SizeCostQuantityStock
10 g $37.10 In stock
50 g $64.90 In stock
100 g $92.50 In stock
Bulk Quote

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Description

Mefenamic acid is a fenamate non-steroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic, neuroprotective, anticancer, and neuromodulatory activities. Mefenamic acid is a non-selective inhibitor of COX-1 and COX-2 that also potentiates activity at GABA-A receptors. In animal models of cerebral ischemia, mefenamic acid decreases infarct volume, edema, and ischemic brain damage. Additionally, this compound inhibits proliferation in colon cancer cells by altering cell cycle regulators and inhibiting store-operated Ca2+ entry into cells.

Product Info

Cas No.

61-68-7
Purity

≥98%
Formula

C15H15NO2
Formula Wt.

241.29
Chemical Name

2-[(2,3-Dimethylphenyl)amino]benzoic acid
IUPAC Name

2-(2,3-dimethylanilino)benzoic acid
Synonym

Bonabol, Coslan, Lysalgo, Mefenacid, Ponstel, Tanston
Melting Point

230-231°C
Solubility

Insoluble in water. Sparingly soluble in ether and chloroform. Soluble in alkali hydroxide solutions.

Appearance

White Micro-Crystalline Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

M1622 MSDS PDF
Info Sheet

M1622 Info Sheet PDF

References

Khansari PS, Halliwell RF. Evidence for neuroprotection by the fenamate NSAID, mefenamic acid. Neurochem Int. 2009 Dec;55(7):683-8. PMID: 19563851.

Weiss H, Amberger A, Widschwendter M, et al. Inhibition of store-operated calcium entry contributes to the anti-proliferative effect of non-steroidal anti-inflammatory drugs in human colon cancer cells. Int J Cancer. 2001 Jun 15;92(6):877-82. PMID: 11351310.

Halliwell RF, Thomas P, Patten D, et al. Subunit-selective modulation of GABAA receptors by the non-steroidal anti-inflammatory agent, mefenamic acid. Eur J Neurosci. 1999 Aug;11(8):2897-905. PMID: 10457186.

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