Mefenamic Acid

Product ID M1622

Cas No. 61-68-7

Purity ≥98%

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Product Info
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Description
Product Info
Shipping and Storage
Downloads
References
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Description

Mefenamic acid is a fenamate non-steroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic, neuroprotective, anticancer, and neuromodulatory activities. Mefenamic acid is a non-selective inhibitor of COX-1 and COX-2 that also potentiates activity at GABA-A receptors. In animal models of cerebral ischemia, mefenamic acid decreases infarct volume, edema, and ischemic brain damage. Additionally, this compound inhibits proliferation in colon cancer cells by altering cell cycle regulators and inhibiting store-operated Ca2+ entry into cells.

Product Info

Cas No.	61-68-7
Purity	≥98%
Formula	C₁₅H₁₅NO₂
Formula Wt.	241.29
Chemical Name	2-[(2,3-Dimethylphenyl)amino]benzoic acid
IUPAC Name	2-(2,3-dimethylanilino)benzoic acid
Synonym	Bonabol, Coslan, Lysalgo, Mefenacid, Ponstel, Tanston
Melting Point	230-231°C
Solubility	Insoluble in water. Sparingly soluble in ether and chloroform. Soluble in alkali hydroxide solutions.
Appearance	White Micro-Crystalline Powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	M1622 MSDS PDF
Info Sheet	M1622 Info Sheet PDF

References

Khansari PS, Halliwell RF. Evidence for neuroprotection by the fenamate NSAID, mefenamic acid. Neurochem Int. 2009 Dec;55(7):683-8. PMID: 19563851.

Weiss H, Amberger A, Widschwendter M, et al. Inhibition of store-operated calcium entry contributes to the anti-proliferative effect of non-steroidal anti-inflammatory drugs in human colon cancer cells. Int J Cancer. 2001 Jun 15;92(6):877-82. PMID: 11351310.

Halliwell RF, Thomas P, Patten D, et al. Subunit-selective modulation of GABAA receptors by the non-steroidal anti-inflammatory agent, mefenamic acid. Eur J Neurosci. 1999 Aug;11(8):2897-905. PMID: 10457186.