LKT Labs

Biochemicals for Life Science Research

Lamotrigine

Product ID L0349
Cas No. 84057-84-1
Purity ≥98%
Product Unit SizeCostQuantityStock
25 mg $114.80 In stock
100 mg $370.50 In stock
500 mg $1,150.10 In stock
Bulk Quote

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Description

Lamotrigine exhibits antiepileptic/anticonvulsant, antidepressant, antinociceptive, and anxiolytic activities. Lamotrigine inhibits R-type Cav2.3 voltage-gated Ca2+ channels and voltage-gated Na+ channels, suppressing release of glutamate. In animals undergoing the forced swim test, lamotrigine decreases immobility time. Lamotrigine also increases pain thresholds in the formalin test and displays anxiolytic properties in the conditioned emotional response test. Lamotrigine may also exhibit anti-inflammatory activity, as it decreases levels of IL-1β, IL-2, and TNF-α in vitro.

Product Info

Cas No.

84057-84-1
Purity

≥98%
Formula

C9H7Cl2N5
Formula Wt.

256.09
Chemical Name

6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine
IUPAC Name

6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine
Melting Point

216-218°C
Solubility

Warm DMSO to 20 mg/mL, warm ethanol to 25 mM, methanol
Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

L0349 MSDS PDF
Info Sheet

L0349 Info Sheet PDF

References

Himmerich H, Bartsch S, Hamer H, et al. Impact of mood stabilizers and antiepileptic drugs on cytokine production in-vitro. J Psychiatr Res. 2013 Nov;47(11):1751-9. PMID: 23978396.

Dibué M, Kamp MA, Alpdogan S, et al. Cav 2.3 (R-type) calcium channels are critical for mediating anticonvulsive and neuroprotective properties of lamotrigine in vivo. Epilepsia. 2013 Sep;54(9):1542-50. PMID: 23772876.

Munro G, Erichsen HK, Mirza NR. Pharmacological comparison of anticonvulsant drugs in animal models of persistent pain and anxiety. Neuropharmacology. 2007 Oct;53(5):609-18. PMID: 17714743.

Kaster MP, Raupp I, Binfaré RW, et al. Antidepressant-like effect of lamotrigine in the mouse forced swimming test: evidence for the involvement of the noradrenergic system. Eur J Pharmacol. 2007 Jun 22;565(1-3):119-24. PMID: 17433291.

Leach MJ, Marden CM, Miller AA. Pharmacological studies on lamotrigine, a novel potential antiepileptic drug: II. Neurochemical studies on the mechanism of action. Epilepsia. 1986 Sep-Oct;27(5):490-7. PMID: 3757936.

Ookubo M, Kanai H, Aoki H, Yamada N. Antidepressants and mood stabilizers effects on histone deacetylase expression in C57BL/6 mice: brain region specific changes. J Psychiatr Res. 2013 Sep;47(9):1204-1214. PMID: 23777937.

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