Lamotrigine

Product ID L0349

Cas No. 84057-84-1

Purity ≥98%

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Description
Product Info
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Downloads
References
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Description

Lamotrigine exhibits antiepileptic/anticonvulsant, antidepressant, antinociceptive, and anxiolytic activities. Lamotrigine inhibits R-type Cav2.3 voltage-gated Ca2+ channels and voltage-gated Na+ channels, suppressing release of glutamate. In animals undergoing the forced swim test, lamotrigine decreases immobility time. Lamotrigine also increases pain thresholds in the formalin test and displays anxiolytic properties in the conditioned emotional response test. Lamotrigine may also exhibit anti-inflammatory activity, as it decreases levels of IL-1β, IL-2, and TNF-α in vitro.

Product Info

Cas No.	84057-84-1
Purity	≥98%
Formula	C₉H₇Cl₂N₅
Formula Wt.	256.09
Chemical Name	6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine
IUPAC Name	6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine
Melting Point	216-218°C
Solubility	Warm DMSO to 20 mg/mL, warm ethanol to 25 mM, methanol
Appearance	White to off white powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	L0349 MSDS PDF
Info Sheet	L0349 Info Sheet PDF

References

Himmerich H, Bartsch S, Hamer H, et al. Impact of mood stabilizers and antiepileptic drugs on cytokine production in-vitro. J Psychiatr Res. 2013 Nov;47(11):1751-9. PMID: 23978396.

Dibué M, Kamp MA, Alpdogan S, et al. Cav 2.3 (R-type) calcium channels are critical for mediating anticonvulsive and neuroprotective properties of lamotrigine in vivo. Epilepsia. 2013 Sep;54(9):1542-50. PMID: 23772876.

Munro G, Erichsen HK, Mirza NR. Pharmacological comparison of anticonvulsant drugs in animal models of persistent pain and anxiety. Neuropharmacology. 2007 Oct;53(5):609-18. PMID: 17714743.

Kaster MP, Raupp I, Binfaré RW, et al. Antidepressant-like effect of lamotrigine in the mouse forced swimming test: evidence for the involvement of the noradrenergic system. Eur J Pharmacol. 2007 Jun 22;565(1-3):119-24. PMID: 17433291.

Leach MJ, Marden CM, Miller AA. Pharmacological studies on lamotrigine, a novel potential antiepileptic drug: II. Neurochemical studies on the mechanism of action. Epilepsia. 1986 Sep-Oct;27(5):490-7. PMID: 3757936.

Ookubo M, Kanai H, Aoki H, Yamada N. Antidepressants and mood stabilizers effects on histone deacetylase expression in C57BL/6 mice: brain region specific changes. J Psychiatr Res. 2013 Sep;47(9):1204-1214. PMID: 23777937.