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BMS-777607

Product ID B4974
Cas No. 1196681-44-3
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $69.50 In stock
5 mg $156.60 Please Inquire
25 mg $422.50 Please Inquire
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  • Description
  • Product Info
  • Shipping and Storage
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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
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Description

BMS-777607 is an inhibitor of MET and Ron that exhibits anticancer chemotherapeutic activity. BMS-777607 induces polyploidy in breast cancer cells by disrupting spindle formation and inhibiting equatorial alignment and chromosomal segregation. This compound also displays anti-metastatic benefit, inhibiting the motility and invasion of sarcoma cells in vitro and decreasing the number of lung tumor nodules in vivo.

Product Info

Cas No.

1196681-44-3

Purity

≥99%

Formula

C25H19ClF2N4O4

Formula Wt.

512.89

Chemical Name

N-[4-(2-amino-3-chloropyridin-4-yl)oxy-3-fluorophenyl]-4-ethoxy-1-(4-fluorophenyl)-2-oxopyridine-3-carboxamide

IUPAC Name

N-[4-(2-amino-3-chloropyridin-4-yl)oxy-3-fluorophenyl]-4-ethoxy-1-(4-fluorophenyl)-2-oxopyridine-3-carboxamide

Synonym

BMS777607

Solubility

DMSO 47 mg/mL (91.63 mM) Water Insoluble Ethanol Insoluble

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

B4974 MSDS PDF

Info Sheet

B4974 Info Sheet PDF

References

Sharma S, Zeng JY, Zhuang CM, et al. Small-molecule inhibitor BMS-777607 induces breast cancer cell polyploidy with increased resistance to cytotoxic chemotherapy agents. Mol Cancer Ther. 2013 May;12(5):725-36. PMID: 23468529.

Dai Y, Bae K, Pampo C, et al. Impact of the small molecule Met inhibitor BMS-777607 on the metastatic process in a rodent tumor model with constitutive c-Met activation. Clin Exp Metastasis. 2012 Mar;29(3):253-61. PMID: 22286523.

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