• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
BMS-777607

BMS-777607

Product ID B4974
Cas No. 1196681-44-3
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $76.70 In stock
5 mg $172.60 Please Inquire
25 mg $465.80 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

BMS-777607 is an inhibitor of MET and Ron that exhibits anticancer chemotherapeutic activity. BMS-777607 induces polyploidy in breast cancer cells by disrupting spindle formation and inhibiting equatorial alignment and chromosomal segregation. This compound also displays anti-metastatic benefit, inhibiting the motility and invasion of sarcoma cells in vitro and decreasing the number of lung tumor nodules in vivo.

Product Info

Cas No.

1196681-44-3

Purity

≥99%

Formula

C25H19ClF2N4O4

Formula Wt.

512.89

Chemical Name

N-[4-(2-amino-3-chloropyridin-4-yl)oxy-3-fluorophenyl]-4-ethoxy-1-(4-fluorophenyl)-2-oxopyridine-3-carboxamide

IUPAC Name

N-[4-(2-amino-3-chloropyridin-4-yl)oxy-3-fluorophenyl]-4-ethoxy-1-(4-fluorophenyl)-2-oxopyridine-3-carboxamide

Synonym

BMS777607

Solubility

DMSO 47 mg/mL (91.63 mM) Water Insoluble Ethanol Insoluble

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

B4974 MSDS PDF

Info Sheet

B4974 Info Sheet PDF

References

Sharma S, Zeng JY, Zhuang CM, et al. Small-molecule inhibitor BMS-777607 induces breast cancer cell polyploidy with increased resistance to cytotoxic chemotherapy agents. Mol Cancer Ther. 2013 May;12(5):725-36. PMID: 23468529.

Dai Y, Bae K, Pampo C, et al. Impact of the small molecule Met inhibitor BMS-777607 on the metastatic process in a rodent tumor model with constitutive c-Met activation. Clin Exp Metastasis. 2012 Mar;29(3):253-61. PMID: 22286523.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • P2510

    4-Phenylbutylisothiocyanate

    Synthetic ITC.

    ≥98%
  • D1760

    3-Acetyl-deoxynivalenol

    Type A trichothecene mycotoxin produced by Fusa...

    ≥98%
  • I4934

    Imipenem Monohydrate

    Carbapenem β-lactam; penicillin binding protei...

    ≥98%
  • T7860

    TTP 22

    Casein kinase 2 inhibitor.

    ≥98%
  • I1257

    Idoxuridine

    Nucleoside (deoxyuridine) analog; DNA chain ter...

    ≥98%
  • T5870

    Torin 1

    Tricyclic benzonaphthyridinone; mTORC1/2 inhibi...

    ≥98%
  • T1968

    Terpinen-4-ol

    Monoterpene found in various plant sources.

    ≥98%
  • C0048

    Cambinol

    SIRT inhibitor.

    ≥98%
  • K0088

    Kawain

    Kavalactone originally found in Piper methystic...

    ≥98%
  • T1675

    Teriparatide Acetate

    Synthetic peptide hormone, PTH analog; PTH1R ag...

    ≥95%
  • P1854

    Penicillic Acid

    Neuroactive mycotoxin produced by Penicillum an...

    ≥98%
  • A5217

    trans-Anethole

    Phenylpropene derivative found in essential oil...

    ≥98%
  • A9600

    AZD-3463

    ALK and IGF-1R inhibitor.

    ≥99%
  • R176485

    Remdesivir

    SARS-CoV-2 inhibitor

    ≥99%
  • C2968

    Chrysin

    Flavone found in Passiflora, Oroxylum, and Pleu...

    ≥98%
  • P1952

    Penitrem A

    Neuroactive mycotoxin produced by Penicillum an...

    ≥97%
  • S0929

    SCH-772984

    ERK1/2 inhibitor.

    ≥97%
  • W9602

    WY-14643

    A peroxisome proliferator-activated receptor ag...

    ≥98%
  • F4883

    Flutriafol

    Triazole; demethylation inhibitor, NMDA agonist...

    ≥97%
  • O6805

    Orbifloxacin

    Fluoroquinolone; bacterial DNA gyrase inhibitor...

    ≥99%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only