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Gastrin-1, like gastrin, is an endogenous peptide hormone that acts as an agonist at the cholestocystokinin 2 (CCK2) receptor, exhibiting anorexigenic and gastrointestinal motility modulating activities. Gastrin inhibits food intake and slows gastric emptying, constricting the pyloric sphincter in vivo. Additionally, gastrin increases release of histamine and induces membrane translocation of the H+/K+ ATPase, stimulating gastric acid release.
| Cas No. | 81123-06-0 |
|---|---|
| Purity | ≥95% |
| Formula | C94H128N22O31S2 |
| Formula Wt. | 2126.32 |
| Solubility | Soluble in 0.1% NaOH (1 mg/mL). |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Furuse M, Ao R, Bungo T, et al. Central gastrin inhibits feeding behavior and food passage in neonatal chicks. Life Sci. 1999;65(3):305-11. PMID: 10447216.
Zimmerhackl B, Wünsch E, Classen M, et al. In man histamine and muscarinergic mechanisms are essential mediators of acid secretion in response to synthetic human gastrin (1-17). Regul Pept. 1993 Jul 23;46(3):583-92. PMID: 8105512.
Rattan S, Coln D, Goyal RK. The mechanism of action of gastrin on the lower esophageal sphincter. Gastroenterology. 1976 May;70(5 PT.1):828-31. PMID: 1261781.
