Name: NLG919
SKU: N4524
Availability: InStock

Description

NLG919 is an inhibitor of indoleamine-2,3-dioxygenase (IDO). This compound displays anticancer chemotherapeutic activity, prolonging survival rates in animal models of glioblastoma.

Product Info

Cas No.	1402836-58-1
Purity	≥98%
Formula	C₁₈H₂₂N₂O
Formula Wt.	282.39
Chemical Name	1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol
IUPAC Name	1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol
Synonym	NLG919 (GDC-0919), GTPL9019
Solubility	Ethanol 30 mg/mL (106.23 mM) DMSO 15 mg/mL warmed (53.11 mM) Water Insoluble

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	N4524 MSDS PDF
Info Sheet	N4524 Info Sheet PDF

References

Vacchelli E, Aranda F, Eggermont A, et al. Trial watch: IDO inhibitors in cancer therapy. Oncoimmunology. 2014 Dec 15;3(10):e957994. PMID: 25941578.

Li M, Bolduc AR, Hoda MN, et al. The indoleamine 2,3-dioxygenase pathway controls complement-dependent enhancement of chemo-radiation therapy against murine glioblastoma. J Immunother Cancer. 2014 Jul 7;2:21. PMID: 25054064.

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NLG919

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