LKT Labs

Biochemicals for Life Science Research

13-cis-Retinoic Acid

Product ID R1779
Cas No. 4759-48-2
Purity 98%
Product Unit SizeCostQuantityStock
100 mg $109.00 In stock
250 mg $190.90 In stock
500 mg $327.00 In stock
Bulk Quote

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Description

13-cis Retinoic acid is an agonist at retinoic acid receptors (RARs) and retinoic X receptors (RXRs); it is clinically used to treat brain cancers and acne vulgaris and exhibits anticancer chemotherapeutic, antioxidative, and anti-inflammatory activities. 13-cis Retinoic acid induces differentiation of various cell types. In animal models of colitis, this compound decreases activity of myeloperoxidase, levels of IL-12, and release of pro-inflammatory cytokines. In vitro, 13-cis retinoic acid also inhibits expression of the angiotensin 1 (AT-1) receptor.

Product Info

Cas No.

4759-48-2
Purity

98%
Formula

C20H28O2
Formula Wt.

300.44
Chemical Name

3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)2-cis-4- trans-6-trans-8-trans-nonatetraenoic acid
IUPAC Name

(2Z,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6, 8-tetraenoic acid
Synonym

Isotretinoin, Isotrex, 13-cis-Vitamin A acid, Teriosal
Melting Point

174-175°C
Solubility

Sparingly soluble in water.
Appearance

Yellow crystalline powder

Shipping and Storage

Store Temp

-80°C
Ship Temp

Ambient

Downloads

MSDS

R1779 MSDS PDF
Info Sheet

R1779 Info Sheet PDF

References

Shah N, Wang J, Selich-Anderson J, et al. PBX1 is a favorable prognostic biomarker as it modulates 13-cis retinoic acid-mediated differentiation in neuroblastoma. Clin Cancer Res. 2014 Aug 15;20(16):4400-12. PMID: 24947929.

Frey-Wagner I, Fischbeck A, Cee A, et al. Effects of retinoids in mouse models of colitis: benefit or danger to the gastrointestinal tract? Inflamm Bowel Dis. 2013 Oct;19(11):2356-65. PMID: 23899542.

Snyder R, Thekkumkara T. 13-cis-Retinoic acid specific down-regulation of angiotensin type 1 receptor in rat liver epithelial and aortic smooth muscle cells. J Mol Endocrinol. 2012 Feb 6;48(2):99-114. PMID: 22180636.

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