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Tamoxifen Citrate

Product ID T0250
Cas No. 54965-24-1
Purity ≥98%
Product Unit SizeCostQuantityStock
500 mg $64.90 In stock
1 g $129.60 In stock
5 g $340.70 In stock
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  • Description
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Description

Tamoxifen is a selective estrogen receptor modulator (SERM) that acts as an ER agonist in the endometrium and as an ER antagonist in breast tissue; it also inhibits PKC. Tamoxifen exhibits anticancer chemotherapeutic, anti-angiogenic, anti-osteoporotic, and antipsychotic activities. Tamoxifen is also a prodrug, transformed into the active metabolite 4-hydroxytamoxifen in vivo. Tamoxifen shows some benefit in clinical settings in the treatment of bipolar I disorder and other mood disorders. In animal models, tamoxifen decreases blood vessel formation and inhibits angiogenesis. In osteoclasts, this compound induces apoptosis by increasing expression of FasL. Additionally, tamoxifen acts as a functional inhibitor of acid sphingomyelinase (FIASMA).

Product Info

Cas No.

54965-24-1

Purity

≥98%

Formula

C26H29NO • C6H8O7

Formula Wt.

563.64

Chemical Name

(Z)-2-(4-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N- dimethylethylamine citrate

IUPAC Name

2-[4-[(Z)-1,2-diphenylbut-1-enyl]phenoxy]-N, N-dimethylethanamine;2-hydroxypropane-1,2,3-tricarboxylic acid InChI: InChI=1S/C26H29NO.C6H8O7/c1-4-25(21-11-7-5-8-12-21)26(22-13-9-6-10-14- 22)23-15-17-24(18-16-23)28-20-19-27(2)3;7-3(8)1-6(13, 5(11)12)2-4(9)10/h5-18H,4,19-20H2,1-3H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11, 12)/b26-25-;

Synonym

Kessar, Nolvadex, Taxus, Zynoplex, Zemide

Melting Point

143-146°C

Solubility

Slightly soluble in water. Soluble in ethanol, methanol or acetone.

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

T0250 MSDS PDF

Info Sheet

T0250 Info Sheet PDF

References

Yildiz A, Guleryuz S, Ankerst DP, et al. Protein kinase C inhibition in the treatment of mania: a double-blind, placebo-controlled trial of tamoxifen. Arch Gen Psychiatry. 2008 Mar;65(3):255-63. PMID: 18316672.

Krum SA, Miranda-Carboni GA, Hauschka PV, et al. Estrogen protects bone by inducing Fas ligand in osteoblasts to regulate osteoclast survival. EMBO J. 2008 Feb 6;27(3):535-45. PMID: 18219273.

Steiner AZ, Terplan M, Paulson RJ. Comparison of tamoxifen and clomiphene citrate for ovulation induction: a meta-analysis. Hum Reprod. 2005 Jun;20(6):1511-5. PMID: 15845599.

Blackwell KL, Haroon ZA, Shan S, et al. Tamoxifen inhibits angiogenesis in estrogen receptor-negative animal models. Clin Cancer Res. 2000 Nov;6(11):4359-64. PMID: 11106254.

Jordan VC. Fourteenth Gaddum Memorial Lecture. A current view of tamoxifen for the treatment and prevention of breast cancer. Br J Pharmacol. 1993 Oct;110(2):507-17. PMID: 8242225.

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