• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
LY-294002 Hydrochloride

LY-294002 Hydrochloride

Product ID L960002
Cas No. 934389-88-5
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $47.80 In stock
5 mg $102.30 In stock
25 mg $293.20 In stock
100 mg $817.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Water soluble form of LY-294002 (L4796). LY-294002 is an inhibitor of PI3K that is used to sensitize cancer cells to other co-administered anticancer chemotherapeutics. In macrophages and monocytes, LY-294002 inhibits NF-κB activity and decreases levels of p50 NF-κB; it also inhibits LPS-induced expression of IL-10. LY-294002 prevents ruffled border formation in osteoclasts by altering the binding of acidic vacuoles with the intercellular membrane. Additionally, this compound inhibits DNA-dependent protein kinase (DPK) activity and prevents the formation of NO.

Product Info

Cas No.

934389-88-5

Purity

≥98%

Formula

C19H17NO3 • HCl

Formula Wt.

343.81

IUPAC Name

2-(4-Morpholinyl)-8-phenyl-4H-chromen-4-one hydrochloride (1:1)

Synonym

LY294002 HCl

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

L960002 MSDS PDF

Info Sheet

L960002 Info Sheet PDF

References

Avni D, Glucksam Y, Zor T. The phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 modulates cytokine expression in macrophages via p50 nuclear factor κB inhibition, in a PI3K-independent mechanism. Biochem Pharmacol. 2012 Jan 1;83(1):106-14. PMID: 22005520.

Salh B, Wagey R, Marotta A, et al. Activation of phosphatidylinositol 3-kinase, protein kinase B, and p70 S6 kinases in lipopolysaccharide-stimulated Raw 264.7 cells: differential effects of rapamycin, Ly294002, and wortmannin on nitric oxide production. J Immunol. 1998 Dec 15;161(12):6947-54. PMID: 9862729.

Nakamura I, Sasaki T, Tanaka S, et al. Phosphatidylinositol-3 kinase is involved in ruffled border formation in osteoclasts. J Cell Physiol. 1997 Aug;172(2):230-9. PMID: 9258344.

Rosenzweig KE, Youmell MB, Palayoor ST, et al. Radiosensitization of human tumor cells by the phosphatidylinositol3-kinase inhibitors wortmannin and LY294002 correlates with inhibition of DNA-dependent protein kinase and prolonged G2-M delay. Clin Cancer Res. 1997 Jul;3(7):1149-56. PMID: 9815794.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • T3197

    L-Thyroxine Sodium Pentahydrate

    Endogenous thyroid hormone T4.

    ≥97%
  • P1754

    Penciclovir

    Nucleoside (guanosine) analog; DNA chain termin...

    ≥98%
  • I7558

    1-Isothiocyanato-9-(methylsulfenyl)-nonane

    ITC, erucin analog.

    ≥97%
  • H0001

    H7

    PKC and PKG inhibitor.

    ≥98%
  • B1977

    Betulin

    Pentacyclic triterpene found in various plant s...

    ≥98%
  • S1609

    Securinine

    Alkaloid found in Securinega; potential GABA-A ...

    ≥98%
  • U6901

    Uracil

    Endogenous pyrimidine base required for product...

    ≥98%
  • M1879

    Metoprolol Tartrate

    β1-adrenergic antagonist.

    ≥98%
  • J8800

    JW55

    TNKS1/2 inhibitor.

    ≥98%
  • G8101

    Guaifenesin

    Expectorant.

    ≥98%
  • B5609

    Boc-GRR-AMC

    Peptide, protease substrate.

    ≥98%
  • X0384

    XAV-939

    Tankyrase inhibitor.

    ≥98%
  • M002698

    M2698

    Dual inhibitor of p70S6K and Akt.

    ≥99%
  • H0207

    Hepatitis B Virus Core Protein (128-140)

    B cell epitope found on hepatitis B viral core ...

    ≥95%
  • S8047

    R,S-Sulforaphane, Research Grade

    Synthetic ITC.

    ≥97%
  • V1871

    Veratridine

    Binds to neurotoxin receptor site 2 on voltage-...

    ≥98%
  • A9834

    Azithromycin Dihydrate

    Azalide macrolide; protein translation inhibito...

    ≥98%
  • A6979

    Dihydroartemisinin

    Sesquiterpene lactone derived from Artemesia; m...

    ≥96%
  • L8248

    Lumiracoxib

    NSAID; COX-2 inhibitor.

    ≥98%
  • T1855

    Tentoxin

    Cyclic peptide mycotoxin produced by Alternaria...

    ≥98%, HPLC

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only