• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
TDZD-8

TDZD-8

Product ID T1298
Cas No. 327036-89-5
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $92.00 In stock
25 mg $337.10 In stock
100 mg $918.80 In stock
250 mg $1,327.20 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

TDZD-8 is an inhibitor of glycogen synthase kinase 3β (GSK-3β) that exhibits anti-inflammatory, anti-arthritic, and neuroprotective activities. TDZD-8 prevents hemorrhagic shock-induced changes in liver microcirculation and hepatocellular injury, inhibiting the inflammatory response and improving liver function in vivo. In rheumatoid arthritis synoviocytes, TDZD-8 decreases levels of p38 MAPK, ATF-2, c-jun, and JNK; in matched animal models, this compound decreases collagen-induced arthritis by inhibiting infiltration of T cells and macrophages as well as decreasing levels of IL-1β, IL-6, TNF-α, and IFN-γ. In other animal models, TDZD-8 improves deficits in spontaneous alternation in the Y-maze and changes in locomotor activity induced by amphetamines and viral-like immune activation.

Product Info

Cas No.

327036-89-5

Purity

≥98%

Formula

C10H10N2O2S

Formula Wt.

222.26

Chemical Name

4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione

IUPAC Name

4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione

Melting Point

63-64.4°C

Solubility

Soluble in DMSO (18mg/mL).

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

T1298 MSDS PDF

Info Sheet

T1298 Info Sheet PDF

References

Jellestad L, Fink T, Pradarutti S, et al. Inhibition of glycogen synthase kinase (GSK)-3-β improves liver microcirculation and hepatocellular function after hemorrhagic shock. Eur J Pharmacol. 2014 Feb 5;724:175-84. PMID: 24389157.

Kwon YJ, Yoon CH, Lee SW, et al. Inhibition of glycogen synthase kinase-3β suppresses inflammatory responses in rheumatoid arthritis fibroblast-like synoviocytes and collagen-induced arthritis. Joint Bone Spine. 2013 Oct 28. [Epub ahead of print]. PMID: 24176738.

Willi R, Harmeier A, Giovanoli S, et al. Altered GSK3β signaling in an infection-based mouse model of developmental neuropsychiatric disease. Neuropharmacology. 2013 Oct;73:56-65. PMID: 23707483.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • B6959

    Bromosporine

    BRD2/4/9 and CECR2 inhibitor.

    ≥99%
  • N8561

    NVP-AEW541

    IGF-1R inhibitor.

    ≥98%
  • A9801

    Azaperone

    Butyrophenone; α-adrenergic, D2, histamine ant...

    ≥98%
  • R8122

    Rufloxacin Hydrochloride

    Fluoroquinolone; topoisomerase IV and bacterial...

    ≥98%
  • G7241

    GSK-461364

    PLK1 inhibitor.

    ≥99%
  • T7035

    Triptolide

    Diterpenoid epoxide found in Tripterygium.

    ≥98%
  • A6804

    Arbutin

    Glycoside hydroquinone originally found in Berg...

    ≥98%
  • G4482

    Glucagon-like Peptide I (7-37)

    Endogenous peptide hormone, GLP-1 fragment, inv...

    ≥95%
  • P7718

    Pterostilbene

    Stilbene, resveratrol analog.

    ≥98%
  • T7860

    TTP 22

    Casein kinase 2 inhibitor.

    ≥98%
  • A9435

    Axitinib

    VEGFR inhibitor.

    ≥98%
  • N3474

    Nisoldipine

    Calcium channel blocker.

    ≥98%
  • H9716

    (E,Z)-4-Hydroxytamoxifen

    Selective estrogen receptor modulator.

    ≥97%
  • M5756

    Montelukast Sodium

    CysLT1 antagonist.

    ≥98%
  • P2002

    PF-04691502 Dihydrate

    PI3K and mTOR inhibitor.

    ≥98%
  • C2951

    Chlortetracycline Hydrochloride

    Tetracycline; protein translation inhibitor, MM...

    ≥85%
  • I7558

    1-Isothiocyanato-9-(methylsulfenyl)-nonane

    ITC, erucin analog.

    ≥97%
  • C9882

    Cytochalasin E

    Mycotoxin produced by Aspergillus; actin polyme...

    ≥98%
  • I1400

    Idarubicin Hydrochloride

    Anthracycline, DNA intercalator; topoisomerase ...

    ≥98%
  • R5722

    Rofecoxib

    NSAID; COX-2 inhibitor.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only