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TDZD-8

Product ID T1298
Cas No. 327036-89-5
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $83.40 In stock
25 mg $305.70 In stock
100 mg $833.30 In stock
250 mg $1,203.80 In stock
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  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

TDZD-8 is an inhibitor of glycogen synthase kinase 3β (GSK-3β) that exhibits anti-inflammatory, anti-arthritic, and neuroprotective activities. TDZD-8 prevents hemorrhagic shock-induced changes in liver microcirculation and hepatocellular injury, inhibiting the inflammatory response and improving liver function in vivo. In rheumatoid arthritis synoviocytes, TDZD-8 decreases levels of p38 MAPK, ATF-2, c-jun, and JNK; in matched animal models, this compound decreases collagen-induced arthritis by inhibiting infiltration of T cells and macrophages as well as decreasing levels of IL-1β, IL-6, TNF-α, and IFN-γ. In other animal models, TDZD-8 improves deficits in spontaneous alternation in the Y-maze and changes in locomotor activity induced by amphetamines and viral-like immune activation.

Product Info

Cas No.

327036-89-5

Purity

≥98%

Formula

C10H10N2O2S

Formula Wt.

222.26

Chemical Name

4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione

IUPAC Name

4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione

Melting Point

63-64.4°C

Solubility

Soluble in DMSO (18mg/mL).

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

T1298 MSDS PDF

Info Sheet

T1298 Info Sheet PDF

References

Jellestad L, Fink T, Pradarutti S, et al. Inhibition of glycogen synthase kinase (GSK)-3-β improves liver microcirculation and hepatocellular function after hemorrhagic shock. Eur J Pharmacol. 2014 Feb 5;724:175-84. PMID: 24389157.

Kwon YJ, Yoon CH, Lee SW, et al. Inhibition of glycogen synthase kinase-3β suppresses inflammatory responses in rheumatoid arthritis fibroblast-like synoviocytes and collagen-induced arthritis. Joint Bone Spine. 2013 Oct 28. [Epub ahead of print]. PMID: 24176738.

Willi R, Harmeier A, Giovanoli S, et al. Altered GSK3β signaling in an infection-based mouse model of developmental neuropsychiatric disease. Neuropharmacology. 2013 Oct;73:56-65. PMID: 23707483.

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