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Paclitaxel Oxetane Ring-Opened 3-Acetyl 4-Benzoyl Impurity

Product ID T1004
Cas No. 932042-85-8
Purity ≥92%
Product Unit SizeCostQuantityStock
1 mg $603.20 In stock
5 mg $2,163.10 In stock
10 mg $3,584.60 In stock
25 mg $7,354.60 Please Inquire
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Description

Paclitaxel Oxetane Ring-Opened 3-Acetyl 4-Benzoyl Impurity is an oxetane ring-opened impurity of Paclitaxel with no significant biological activity. It is also known as paclitaxel impurity M.

Product Info

Cas No.

932042-85-8

Purity

≥92%

Formula

C47H53NO15

Formula Wt.

871.92

Chemical Name

β-(Benzoylamino)-α-hydroxybenzenepropanoic Acid (αR,βS)-(1S,3S,4S,4aR,5S,6S,8S,11R,12aS)-3,11-Bis(acetyloxy)-4-[(benzoyloxy)methyl]-1,2,3,4,4a,5,6,7,8,11,12,12a-dodecahydro-1,4,5,6-tetrahydroxy-9,12a,13,13-tetramethyl-12-oxo-6,10-methanobenzocyclodecen-8-yl Ester

IUPAC Name

[(1S,2S,3R,4S,5S,7S,8S,10R,13S)-5,10-bis(acetyloxy)-1,2,4,7-tetrahydroxy-13-{[(2R,3S)-2-hydroxy-3-phenyl-3-(phenylformamido)propanoyl]oxy}-8,12,15,15-tetramethyl-9-oxotricyclo[9.3.1.03,8]pentadec-11-en-4-yl]methyl benzoate

Synonym

Paclitaxel, Oxetane Ring Opened, Acetyl and Benzoyl Migrated; paclitaxel impurity M

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

T1004 MSDS PDF

Info Sheet

T1004 Info Sheet PDF

References

Nicolaou K, Yang Z, Liu J, et al. Total synthesis of taxol. Nature. 1994 Feb 17;367(6464):630-634. PMID: 7906395.

Nicolaou K, Valiulin R. Synthesis and biological evaluation of new paclitaxel analogs and discovery of potent antitumor agents. Org Biomol Chem. 2013 Jul 7;11(25):4154-4163. PMID: 23685867.

Sanchez-Munoz R, Perez-Mata E, Almagro L, et al. A novel hydroxylation step in the taxane biosynthetic pathway: a new approach to paclitaxel production by synthetic biology. Front Bioeng Biotechnol. 2020 May 13;8::410. PMID: 32528936.

Guo B, Kai G, Jin H, et al. Taxol synthesis. African J Biotechnol. 2006 Jan 2;5(1):15-20.

Wang T, Chen Y, Zhuang W, et al. Transcriptome sequencing reveals regulatory mechanisms of taxol synthesis in Taxus wallichiana var. Mairei. Int J Genomics. 2019 May 2;2019:1596895. PMID: 31192250.

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