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Adagrasib

Product ID A121008
Cas No. 2326521-71-3
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $135.00 In stock
5 mg $245.00 In stock
25 mg $595.00 In stock
100 mg $1,500.00 In stock
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  • Description
  • Product Info
  • Shipping and Storage
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  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Adagrasib is a inhibitor of KRASG12C, which is a notoriously difficult to treat cancerous mutation.

Product Info

Cas No.

2326521-71-3

Purity

≥99%

Formula

C32H35ClFN7O2

Formula Wt.

604.13

IUPAC Name

2-[(2S)-4-[7-(8-chloronaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]-1-(2-fluoroprop-2-enoyl)piperazin-2-yl]acetonitrile

Synonym

MRTX-849

Appearance

White powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

Info Sheet

A121008 Info Sheet PDF

References

Zhang Y, Li C, Xia C, et al. Adagrasib, a KRAS G12c inhibitor, reverses the multidrug resistance mediated by ABCB1 in vitro and in vivo. Cell Commun Signal. 2022 Sep 14;20(1):142. PMID: 36104708

Sabari J, Velcheti V, Shimizu K, et al. Activity of adagrasib (MRTX849) in brain metastases: preclinical models and clinical data from patients with KRASG12c-mutant non-small cell lung cancer. Clin Cancer Res. 2022 Aug 2;28(15):3318-3328. PMID: 35404402

Koga T, Suda K, Fujino T, et al. KRAS secondary mutations that confer acquired resistance to KRAS G12c inhibitors, sotorasib and adagrasib, and overcoming strategies: insights form in vitro experiments. J Thorac Oncol. 2021 Aug;16(8):1321-1332. PMID: 33971321

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