• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Everolimus

Everolimus

Product ID E8419
Cas No. 159351-69-6
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $61.10 In stock
5 mg $137.90 In stock
25 mg $330.80 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Everolimus is an inhibitor of mammalian target of rapamycin 1 (mTOR1) that is used clinically for its immunosuppressive activity in renal transplant recipients and is currently in clinical trials exploring its anticancer chemotherapeutic activity. In nasopharyngeal carcinoma cells, everolimus induces apoptosis and autophagy, inhibiting cell growth. In esophageal cancer cells, everolimus decreases expression of mTOR targets p70S6K and S6, increasing cell damage and decreasing cell proliferation. In animal models of experimental autoimmune uveoretinitis (EAU), everolimus decreases levels of Th1, Th2, and Th17 cytokines and increases levels of Treg cells, attenuating disease pathology. Additionally, everolimus exhibits nephroprotective benefit at low doses, decreasing adriamycin-induced proteinuria and improving renal function in animal models of nephrotic syndrome.

Product Info

Cas No.

159351-69-6

Purity

≥98%

Formula

C53H83NO14

Formula Wt.

958.22

Chemical Name

40-O-(2-hydroxyethyl)-sirolimus

IUPAC Name

Dihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.0 hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone

Synonym

Certican, SDZ RAD, 40-O-(2-hydroxyethyl)-rapamycin, RAD001

Melting Point

95-110°C

Solubility

Insoluble in water. Soluble in DMSO (30mg/mL), ethanol (7 mg/mL).

Appearance

White to off white powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

E8419 MSDS PDF

Info Sheet

E8419 Info Sheet PDF

Brochures

PI3K-Akt-mTORC Pathway Booklet

References

Sendur MA, Zengin N, Aksoy S, et al. Everolimus: a new hope for patients with breast cancer. Curr Med Res Opin. 2014 Jan;30(1):75-87. PMID: 24050600.

Cai Y, Xia Q, Su Q, et al. mTOR inhibitor RAD001 (everolimus) induces apoptotic, not autophagic cell death, in human nasopharyngeal carcinoma cells. Int J Mol Med. 2013 Apr;31(4):904-12. PMID: 23426850.

Hennig M, Bauer D, Wasmuth S, et al. Everolimus improves experimental autoimmune uveoretinitis. Exp Eye Res. 2012 Dec;105:43-52. PMID: 23059401.

Ramadan R, Faour D, Awad H, et al. Early treatment with everolimus exerts nephroprotective effect in rats with adriamycin-induced nephrotic syndrome. Nephrol Dial Transplant. 2012 Jun;27(6):2231-41. PMID: 22036940.

Wang ZG, Fukazawa T, Nishikawa T, et al. RAD001 offers a therapeutic intervention through inhibition of mTOR as a potential strategy for esophageal cancer. Oncol Rep. 2010 Apr;23(4):1167-72. PMID: 20204306.

Kahan BD, Koch SM. Current immunosuppressant regimens: considerations for critical care. Curr Opin Crit Care. 2001 Aug;7(4):242-50. PMID: 11571421.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • S7870

    Streptozocin

    Nitrosourea-amino sugar conjugate, DNA cross-li...

    ≥98%
  • G3460

    Ginsenoside F1

    Triterpene saponin found in species of Panax.

    ≥98%
  • L4796

    LY-294002

    PI3K inhibitor.

    ≥99%
  • E0929

    Echinacoside

    Phenylethanoid glycoside found in Echinacea.

    ≥98%
  • R3374

    Risedronic Acid

    Bisphosphonate; inhibits transfer of farnesyl p...

    ≥97%
  • V344766

    Vitexin

    Found in hawthorn.

    ≥98%
  • S3343

    Silybin

    Flavonoid originally found in Silybum (milk thi...

    ≥97%
  • D0032

    Daidzein

    Phytoestrogen, isoflavone found in various plan...

    ≥97%
  • S9775

    Systemin

    Peptide hormone found in Solanaceae family plan...

    ≥95%
  • T3035

    Thienylheptyl Isothiocyanate

    Thienylbutyl ITC analog.

    ≥95%
  • C3250

    Cimetidine

    Histamine H2 and AR antagonist, catalase inhibi...

    ≥99%
  • E7357

    Esomeprazole Potassium

    (S) isomer of omeprazole; H+/K+ ATPase and MAO-...

    ≥98%
  • F8250

    Fumitremorgin C

    Mycotoxin found in Aspergillus and Penicillum; ...

    ≥98%
  • A081014

    Acalabrutinib

    Inhibitor of Bruton’s tyrosine kinase (BTK).<...

    ≥99%
  • D5649

    Domperidone

    D2/3 antagonist, hERG K+ channel blocker.

    ≥98%
  • M1752

    Men 10376

    Peptide; NK2 antagonist.

    ≥95%
  • R3475

    Risperidone

    Benzisoxazole; 5-HT7 and NMDA agonist, D-amino ...

    ≥98%
  • A9817

    Azelaic Acid

    Dicarboxylic acid found in Arabidopsis; PPARγ ...

    ≥98%
  • G7346

    GSK-2636771

    p110β PI3K inhibitor.

    ≥98%
  • A7071

    Atriopeptin II, rat/rabbit/mouse

    ANP analog, cardiomodulatory peptide; NPR-A ago...

    ≥95%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only