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Dorsomorphin Dihydrochloride

Product ID D582705
Cas No. 1219168-18-9
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $121.10 In stock
10 mg $166.90 In stock
25 mg $383.10 In stock
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  • Description
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Description

Water soluble form of dorsomorphin (D582703), a selective and potent inhibitor of bone morphogenetic protein (BMP) through the receptors ALK2, ALK3, and ALK6. Inhibits AMPK, inducing autophagy in cancer cells. Shown to promote functional myogenesis along with LDN-193189.

Product Info

Cas No.

1219168-18-9

Purity

≥98%

Formula

C24H27Cl2N5O

Formula Wt.

472.41

IUPAC Name

6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine;dihydrochloride

Synonym

Dorsomorphin 2HCl; BML-275; BML-275 2HCl; Compound C; AK175513; 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine;dihydrochloride

Solubility

Water (100 mM), DMSO (20 mM).

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

D582705 MSDS PDF

Info Sheet

D582705 Info Sheet PDF

References

Yu P., Hong C., et al. Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nat Chem Biol. 34(1):33-41 (2008). PMID: 18026094.

Vucicevic L., Misirkic M., et al. Compound C induces protective autophagy in cancer cells through AMPK inhibition-independent blockade of Akt/mTOR pathway. Autophagy. 7(1):40-50 (2011). PMID: 20980833.

Horbelt D., Boergermann J., et al. Small molecules dorsomorphin and LDN-193189 inhibit myostatin/GDF8 signaling and promote functional myoblast differentiation. J Biol Chem. 290(6):3390-404 (2015). PMID: 25368322.

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