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Dorsomorphin

Product ID D582703
Cas No. 866405-64-3
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $96.50 In stock
10 mg $158.30 In stock
25 mg $368.30 In stock
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  • Description
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Description

Dorsomorphin is a selective and potent inhibitor of bone morphogenetic protein (BMP) through the receptors ALK2, ALK3, and ALK6. Inhibits AMPK, inducing autophagy in cancer cells. Shown to promote functional myogenesis along with LDN-193189.

Product Info

Cas No.

866405-64-3

Purity

≥98%

Formula

C24H25N5O

Formula Wt.

399.50

IUPAC Name

6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine

Synonym

BML-275; Compound C; 6-(4-(2-(Piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine; AMPK inhibitor, compound C

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

D582703 MSDS PDF

Info Sheet

D582703 Info Sheet PDF

References

Yu P., Hong C., et al. Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nat Chem Biol. 34(1):33-41 (2008). PMID: 18026094.

Vucicevic L., Misirkic M., et al. Compound C induces protective autophagy in cancer cells through AMPK inhibition-independent blockade of Akt/mTOR pathway. Autophagy. 7(1):40-50 (2011). PMID: 20980833.

Horbelt D., Boergermann J., et al. Small molecules dorsomorphin and LDN-193189 inhibit myostatin/GDF8 signaling and promote functional myoblast differentiation. J Biol Chem. 290(6):3390-404 (2015). PMID: 25368322.

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