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Dorsomorphin is a selective and potent inhibitor of bone morphogenetic protein (BMP) through the receptors ALK2, ALK3, and ALK6. Inhibits AMPK, inducing autophagy in cancer cells. Shown to promote functional myogenesis along with LDN-193189.
| Cas No. | 866405-64-3 |
|---|---|
| Purity | ≥98% |
| Formula | C24H25N5O |
| Formula Wt. | 399.50 |
| IUPAC Name | 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine |
| Synonym | BML-275; Compound C; 6-(4-(2-(Piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine; AMPK inhibitor, compound C |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Yu P., Hong C., et al. Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nat Chem Biol. 34(1):33-41 (2008). PMID: 18026094.
Vucicevic L., Misirkic M., et al. Compound C induces protective autophagy in cancer cells through AMPK inhibition-independent blockade of Akt/mTOR pathway. Autophagy. 7(1):40-50 (2011). PMID: 20980833.
Horbelt D., Boergermann J., et al. Small molecules dorsomorphin and LDN-193189 inhibit myostatin/GDF8 signaling and promote functional myoblast differentiation. J Biol Chem. 290(6):3390-404 (2015). PMID: 25368322.
