Description
BML-277 (Chk2 Inhibitor II) is an arylbenzimidazole inhibitor of checkpoint kinase (CHK) 2. This compound displays cytoprotective activity, protecting CD4+ and CD8+ T cells against radiation-induced apoptosis.
Product Unit Size | Cost | Quantity | Stock |
---|
BML-277 (Chk2 Inhibitor II) is an arylbenzimidazole inhibitor of checkpoint kinase (CHK) 2. This compound displays cytoprotective activity, protecting CD4+ and CD8+ T cells against radiation-induced apoptosis.
Cas No. | 516480-79-8 |
---|---|
Purity | ≥98% |
Formula | C20H14ClN3O2 |
Formula Wt. | 363.80 |
Chemical Name | 2-[4-(4-Chlorophenoxy)phenyl]-1H-benzimidazole-5-carboxamide |
IUPAC Name | 2-[4-(4-Chlorophenoxy)phenyl]-1H-benzimidazole-5-carboxamide |
Synonym | Chk2 Inhibitor II |
Solubility | DMSO 72 mg/mL Ethanol 21 mg/mL Water Insoluble |
Store Temp | -20°C |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet |
Arienti KL, Brunmark A, Axe FU, et al. Checkpoint kinase inhibitors: SAR and radioprotective properties of a series of 2-arylbenzimidazoles. J Med Chem. 2005 Mar 24;48(6):1873-85. PMID: 15771432.
Serotonin/melatonin analog found in various pla...
Recombinant HCV antigen fragment.
Endogenous hormone and neurotransmitter involve...
Electron carrier used to study dehydrogenase el...
Peptide, carbonic anhydrase G250 epitope.
AMPK activator.
Synthetic peptide; dermorphin analog; δOR and ...
Antimicrobial peptide found in Apis mellifera.<...
Indole derivative found in Isatis, Calanthe, an...
Flavonoid found in various plant sources; GABA-...
Endogenous bile acid; FXR agonist.
Prolyl hydroxylase inhibitor.
Serine protease substrate/inhibitor.
(S) isomer of omeprazole; H+/K+ ATPase and MAO-...
SK K+ channel blocker, EGFR inhibitor.
Cathepsin K inhibitor.
Abl inhibitor.
Synthetic compound related to sulforaphane.
Sulfonamide; dihydropteroate synthase inhibitor...
Specific inhibitor of histone methyltransferase...