Toremifene Base

Name: Toremifene Base
SKU: T5769
Availability: InStock

Product ID T5769

Cas No. 89778-26-7

Purity ≥98%

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Description

Toremifene is a selective estrogen receptor modulator (SERM) that also moderates androgen receptor activity as well. Toremifene displays anticancer chemotherapeutic and anti-angiogenic activities. Clinically, this compound is used to treat breast cancer and prostate cancer. Toremifene decreases microvessel density and induces remission of benign fibrous lesions in clinical settings with subjects experiencing desmoid tumors. Additionally, toremifene increases latency to tumor formation, decreases tumor number, and increases survival in animal models of prostate cancer.

Product Info

Cas No.	89778-26-7
Purity	≥98%
Formula	C₂₆H₂₈ClNO
Formula Wt.	405.96
Chemical Name	2-[4-[(1Z)-4-Chloro-1,2-diphenyl-1-butenyl]phenoxy]-N,N-dimethylethanamine
IUPAC Name	2-[4-[(Z)-4-chloro-1,2-diphenylbut-1-enyl]phenoxy]-N, N-dimethylethanamine
Synonym	Toremifene
Melting Point	108-110°C
Appearance	White Crystal Powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	T5769 MSDS PDF
Info Sheet	T5769 Info Sheet PDF

References

Chang BY, Kim SA, Malla B, et al. The Effect of Selective Estrogen Receptor Modulators (SERMs) on the Tamoxifen Resistant Breast Cancer Cells. Toxicol Res. 2011 Jun;27(2):85-93. PMID: 24278556.

Kawashima H, Tanaka T, Cheng JS, et al. Effect of anti-estrogens on the androgen receptor activity and cell proliferation in prostate cancer cells. Urol Res. 2004 Dec;32(6):406-10. PMID: 15316697.

Heidemann J, Ogawa H, Otterson MF, et al. Antiangiogenic treatment of mesenteric desmoid tumors with toremifene and interferon alfa-2b: report of two cases. Dis Colon Rectum. 2004 Jan;47(1):118-22. PMID: 14719159.

Raghow S, Hooshdaran MZ, Katiyar S, et al. Toremifene prevents prostate cancer in the transgenic adenocarcinoma of mouse prostate model. Cancer Res. 2002 Mar 1;62(5):1370-6. PMID: 11888907.

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Toremifene Base

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