• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Rhein

Rhein

Product ID R2917
Cas No. 478-43-3
Purity ≥88%
Product Unit SizeCostQuantityStock
100 mg $142.90 In stock
500 mg $571.60 In stock
1 g $1,061.80 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Rhein is an active metabolite of diacerein and an anthraquinone found in Rheus (rhubarb). Rhein exhibits pro-inflammatory, anti-inflammatory, anti-diabetic, anticancer, antioxidative, anti-atherosclerotic, and anti-angiogenic activities. Rhein inhibits LPS-induced activation of NF-κB and production of IL-6 and IL-1β by inhibiting degradation of IκB kinase. Rhein also inhibits hyperglycemia-induced apoptosis in β cells in animal models of diabetes. In gastric cancer cells, rhein increases the Bax/Bcl-2 ratio and levels of cytochrome c, inducing mitochondria-mediated apoptosis and inhibiting cell proliferation. This compound also inhibits vessel plexus formation and endothelial cell migration. Additionally, rhein decrease H2O2-induced increases in malondialdehyde and lactate dehydrogenase levels and decreases in superoxide dismutase and glutathione activity, inhibiting apoptosis and oxidative injury.

Product Info

Cas No.

478-43-3

Purity

≥88%

Formula

C15H8O6

Formula Wt.

284.22

Chemical Name

9,10-Dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid

IUPAC Name

4,5-dihydroxy-9,10-dioxoanthracene-2-carboxylic acid

Synonym

Rhubarb yellow, Monorhein, Rheic acid, Cassic acid, Parietic acid

Melting Point

321-322°C

Solubility

Practically insoluble in water. Soluble in alkalies and pyridine.

Appearance

Yellow needle crystals

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

R2917 MSDS PDF

Info Sheet

R2917 Info Sheet PDF

References

Gao Y, Chen X, Fang L, et al. Rhein exerts pro- and anti-inflammatory actions by targeting IKKβ inhibition in LPS-activated macrophages. Free Radic Biol Med. 2014 Jul;72:104-12. PMID: 24721152.

Liu J, Chen Z, Zhang Y, et al. Rhein protects pancreatic β-cells from dynamin-related protein-1-mediated mitochondrial fission and cell apoptosis under hyperglycemia. Diabetes. 2013 Nov;62(11):3927-35. PMID: 23919963.

Li Y, Xu Y, Lei B, et al. Rhein induces apoptosis of human gastric cancer SGC-7901 cells via an intrinsic mitochondrial pathway. Braz J Med Biol Res. 2012 Nov;45(11):1052-9. PMID: 22850871.

Zhong XF, Huang GD, Luo T, et al. Protective effect of rhein against oxidative stress-related endothelial cell injury. Mol Med Rep. 2012 May;5(5):1261-6. PMID: 22344690.

He ZH, Zhou R, He MF, et al. Anti-angiogenic effect and mechanism of rhein from Rhizoma Rhei. Phytomedicine. 2011 Apr 15;18(6):470-8. PMID: 21112197.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A985132

    AZD-8186

    Selective inhibitor of PI3Kβ and PI3Kδ.

    ≥99%
  • P6818

    Prednisolone

    Cortisol derivative; glucocorticoid agonist.

    ≥98%
  • R0247

    Raltegravir

    HIV integrase inhibitor.

    ≥99%
  • U6802

    Urapidil Hydrochloride

    5-HT1A agonist, α1-adrenergic antagonist.

    ≥98%
  • E5575

    Entacapone

    COMT inhibitor.

    ≥98%
  • S0501

    SB-939

    HDAC inhibitor.

    ≥98%
  • H0002

    H8 dihydrochloride

    PKA inhibitor.

    ≥98%
  • K0023

    K252c

    Staurosporine analog; PKC and PKA inhibitor.

    ≥98%
  • C0255

    Cantharidin

    Toxin produced by Canarthis vesicatoria; PP1/2A...

    ≥98%
  • H9812

    5-Hydroxytryptophol

    Serotonin/melatonin analog found in various pla...

    ≥98%
  • N3228

    Nifedipine

    Dihydropyridine; L-type Ca2+ channel blocker.

    ≥98%
  • O7332

    OSI-027

    mTOR inhibitor.

    ≥99%
  • V1600

    VE-821

    ATR inhibitor.

    ≥98%
  • N7208

    NSC-74859

    STAT3 inhibitor.

    ≥98%
  • D8276

    Dutasteride

    5-α-Reductase inhibitor.

    ≥99%
  • T5869

    Torcetrapib

    Cholesterol ester transfer protein inhibitor.

    ≥98%
  • O9702

    Ozagrel Hydrochloride

    TxA2 synthase inhibitor.

    ≥98%
  • T2935

    Thiamphenicol

    Chloramphenicol derivative; protein translation...

    ≥98%
  • B5072

    BMS-754807

    InsR and IGF-1R inhibitor.

    ≥99%
  • I0010

    5-(9-Isopropyl-2-morpholino-9H-purin-6-yl)pyrimidin-2-amine

    Intermediate in the synthesis of purine analogs...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only