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MK-2206 Dihydrochloride

Product ID M400220
Cas No. 1032350-13-2
Purity ≥99%
Product Unit SizeCostQuantityStock
5 mg $55.70 In stock
25 mg $154.60 In stock
100 mg $432.60 In stock
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  • Product Info
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  • Description
  • Product Info
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Description

MK-2206 is an allosteric inhibitor of Akt that prevents translocation of Akt to membranes. MK-2206 exhibits anticancer chemotherapeutic activity in a variety of in vitro cancer models; this compound induces G1-phase cell cycle arrest in hepatocellular carcinoma cells, inhibits cell proliferation in non-small cell lung cancer cells, and inhibits proliferation in medullary thyroid cancer cells. In animal models of nasopharyngeal cancer, MK-2006 inhibits tumor growth.

Product Info

Cas No.

1032350-13-2

Purity

≥99%

Formula

C25H21N5O • 2HCl

Formula Wt.

480.39

Chemical Name

MK-2206 Dihydrochloride

IUPAC Name

8-[4-(1-Aminocyclobutyl)phenyl]-9-phenyl[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3(2H)-one dihydrochloride

Synonym

MK-2206 hydrochloride

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

M400220 MSDS PDF

Info Sheet

M400220 Info Sheet PDF

References

Zhao YY, Tian Y, Zhang J, et al. Effects of an oral allosteric AKT inhibitor (MK-2206) on human nasopharyngeal cancer in vitro and in vivo. Drug Des Devel Ther. 2014 Oct 10;8:1827-37. pMID: 25336925.

Burke JF, Schlosser L, Harrison AD, et al. MK-2206 Causes Growth Suppression and Reduces Neuroendocrine Tumor Marker Production in Medullary Thyroid Cancer Through Akt Inhibition. Ann Surg Oncol. 2013 Nov;20(12):3862-8. PMID: 23900743.

Jiao P, Zhou YS, Yang JX, et al. MK-2206 induces cell cycle arrest and apoptosis in HepG2 cells and sensitizes TRAIL-mediated cell death. Mol Cell Biochem. 2013 Jun 25. [Epub ahead of print] PMID: 23797319.

Jin R, Nakada M, Teng L, et al. Combination therapy using Notch and Akt inhibitors is effective for suppressing invasion but not proliferation in glioma cells. Neurosci Lett. 2013 Feb 8;534:316-21. PMID: 23262078.

Quayle SN, Lee JY, Cheung LW, et al. Somatic mutations of PIK3R1 promote gliomagenesis. PLoS One. 2012;7(11):e49466. PMID: 23166678.

Iida M, Brand TM, Campbell DA, et al. Targeting AKT with the allosteric AKT inhibitor MK-2206 in non-small cell lung cancer cells with acquired resistance to cetuximab. Cancer Biol Ther. 2013 Jun;14(6):481-91. PMID: 23760490.

Davies BR, Greenwood H, Dudley P, et al. Preclinical pharmacology of AZD5363, an inhibitor of AKT: pharmacodynamics, antitumor activity, and correlation of monotherapy activity with genetic background. Mol Cancer Ther. 2012 Apr;11(4):873-87. PMID: 22294718.

Cheng Y, Zhang Y, Zhang L, et al. MK-2206, a novel allosteric inhibitor of Akt, synergizes with gefitinib against malignant glioma via modulating both autophagy and apoptosis. Mol Cancer Ther. 2012 Jan;11(1):154-64. PMID: 22057914.

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