Description
Kobe 0065 is an inhibitor of Ras that exhibits anticancer chemotherapeutic activities. In vitro, this compound inhibits cell growth and induces apoptosis and in vivo, it decreases tumor growth.
Product Info
| Cas No. | 436133-68-5 |
|---|---|
| Purity | ≥99% |
| Formula | C15H11ClF3N5O4S |
| Formula Wt. | 449.79 |
| IUPAC Name | N-(3-Chloro-4-methylphenyl)-2-[2,6-dinitro-4-(trifluoromethyl)phenyl]hydrazinecarbothioamide |
| Solubility | ethanol 10mM with gentle warming water 5 mM with gentle warming |
Shipping and Storage
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
Downloads
| MSDS | |
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| Info Sheet |
References
Shima F, Yoshikawa Y, Ye M, et al. In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction. Proc Natl Acad Sci U S A. 2013 May 14;110(20):8182-7. PMID: 23630290.
Shima F, Yoshikawa Y, Matsumoto S, et al. Discovery of small-molecule Ras inhibitors that display antitumor activity by interfering with Ras·GTP-effector interaction. Enzymes. 2013;34 Pt. B:1-23. PMID: 25034098.