Description
Kobe 0065 is an inhibitor of Ras that exhibits anticancer chemotherapeutic activities. In vitro, this compound inhibits cell growth and induces apoptosis and in vivo, it decreases tumor growth.
Product Unit Size | Cost | Quantity | Stock |
---|
Kobe 0065 is an inhibitor of Ras that exhibits anticancer chemotherapeutic activities. In vitro, this compound inhibits cell growth and induces apoptosis and in vivo, it decreases tumor growth.
Cas No. | 436133-68-5 |
---|---|
Purity | ≥99% |
Formula | C15H11ClF3N5O4S |
Formula Wt. | 449.79 |
IUPAC Name | N-(3-Chloro-4-methylphenyl)-2-[2,6-dinitro-4-(trifluoromethyl)phenyl]hydrazinecarbothioamide |
Solubility | ethanol 10mM with gentle warming water 5 mM with gentle warming |
Store Temp | -20°C |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet |
Shima F, Yoshikawa Y, Ye M, et al. In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction. Proc Natl Acad Sci U S A. 2013 May 14;110(20):8182-7. PMID: 23630290.
Shima F, Yoshikawa Y, Matsumoto S, et al. Discovery of small-molecule Ras inhibitors that display antitumor activity by interfering with Ras·GTP-effector interaction. Enzymes. 2013;34 Pt. B:1-23. PMID: 25034098.
BTK inhibitor.
5-HT1A agonist, α1-adrenergic antagonist.
Chalcone kavalactone found in Piper methysticum...
Phenol found in Zingiber; PPARγ agonist, 5-HT3...
Tamoxifen analog; SERM.
Thiamine/vitamin B derivative, antioxidant.
Mixture found in Croton, used to induce inflamm...
Nucleoside (adenosine) analog; viral DNA polyme...
EZH2 inhibitor
Endogenous peptide, involved in paracrine and a...
Endogenous prostaglandin, vasodilator.
Endogenous quaternary ammonium, required for fa...
Docetaxel impurity
Resveratrol prodrug; potential SIRT1 activator....
GHB agonist, D2/3 antagonist.
Triazole; 14-α demethylase inhibitor, voltage-...
JAK2 inhibitor.
PI3K inhibitor.
Ca2+ ATPase and ATP-sensitive K+ channel activa...
Endogenous bombesin-like peptide, involved in f...