LKT Labs

Biochemicals for Life Science Research

Diclofenac Impurity C

Product ID D324090
Cas No. 27204-57-5
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $115.30 In stock
25 mg $353.20 In stock
100 mg $1,059.50 In stock
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Description

Diclofenac Impurity C (Diclofenac EP impurity C) is an impurity of Diclofenac.

Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) that is clinically used to treat inflammation associated with arthritis and gout as well as other pain or inflammatory disorders; it is somewhat selective in inhibiting COX-2 over COX-1. Diclofenac exhibits anti-inflammatory, antipyretic, analgesic, antinociceptive, anticonvulsant, anti-angiogenic, anticancer chemotherapeutic, and chemopreventive activities. In vitro, the anticonvulsant/antiepileptic activity of diclofenac may stem from inhibition of delayed rectifier K+ channel amplitude and acceleration of channel inactivation; it also increases the amplitude of M-type K+ channels. This compound inhibits DMH-induced colon carcinogenesis in vivo, decreasing levels of COX-2, VEGF, and MCP-1. Diclofenac also decreases the epithelial-to-mesenchymal transition (EMT), suppressing squamous cell carcinoma tumor growth.

Product Info

Cas No.

27204-57-5
Purity

≥98%
Formula

C13H11Cl2NO
Formula Wt.

268.14
Chemical Name

[2-[(2,6-Dichlorophenyl)amino]phenyl]methanol
Synonym

Diclofenac EP impurity C; Diclofenac impurity 3; 2-[(2,6-Dichlorophenyl)amino]benzenemethanol; o-(2,6-Dichloroanilino)benzyl Alcohol ;Diclofenac Alcohol.

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

D324090 MSDS PDF
Info Sheet

D324090 Info Sheet PDF

References

Arumugam A, Weng Z, Talwelkar SS, et al. Inhibiting cycloxygenase and ornithine decarboxylase by diclofenac and alpha-difluoromethylornithine blocks cutaneous SCCs by targeting Akt-ERK axis. PLoS One. 2013 Nov 8;8(11):e80076. PMID: 24260338.

Akbari E, Mirzaei E, Shahabi Majd N. Long-term Morphine-treated Rats are more Sensitive to Antinociceptive Effect of Diclofenac than the Morphine-naive rats. Iran J Pharm Res. 2013 Winter;12(1):175-84. PMID: 24250586.

Huang CW, Hung TY, Liao YK, et al. Underlying mechanism of regulatory actions of diclofenac, a nonsteroidal anti-inflammatory agent, on neuronal potassium channels and firing: an experimental and theoretical study. J Physiol Pharmacol. 2013 Jun;64(3):269-80. PMID: 23959723.

Kaur J, Sanyal SN. Diclofenac, a selective COX-2 inhibitor, inhibits DMH-induced colon tumorigenesis through suppression of MCP-1, MIP-1α and VEGF. Mol Carcinog. 2011 Sep;50(9):707-18. PMID: 21268133.

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