Dermaseptin is a cationic antimicrobial peptide (AMP) that exhibits antibacterial activity against Acinetobacter and Pseudomonas. Dermaseptin increases permeability of cell membranes. Dermaseptin also exhibits anticancer chemotherapeutic and anti-angiogenic activities, inhibiting proliferation, colony formation, and capillary formation in vitro as well as tumor growth in animal models of prostate adenocarcinoma.
| Purity | ≥96% |
|---|---|
| Formula | C152H257N43O44S2 |
| Formula Wt. | 3455.08 |
| Chemical Name | Ala-Leu-Trp-Lys-Thr-Met-Leu-Lys-Lys-Leu-Gly-Thr-Met-Ala-Leu-His-Ala-Gly-Lys-Ala-Ala-Leu-Gly-Ala-Ala-Ala-Asp-Thr-Ile-Ser-Gln-Gly-Thr-Gln |
| Solubility | Soluble in water. |
| Appearance | White to off-white powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
|---|---|
| Info Sheet |
Jiang Z, Vasil AI, Vasil ML, et al. "Specificity Determinants" Improve Therapeutic Indices of Two Antimicrobial Peptides Piscidin 1 and Dermaseptin S4 Against the Gram-negative Pathogens Acinetobacter baumannii and Pseudomonas aeruginosa. Pharmaceuticals (Basel). 2014 Mar 25;7(4):366-91. PMID: 24670666.
Caillon L, Killian JA, Lequin O, et al. Biophysical investigation of the membrane-disrupting mechanism of the antimicrobial and amyloid-like peptide dermaseptin S9. PLoS One. 2013 Oct 11;8(10):e75528. PMID: 24146759.
van Zoggel H, Carpentier G, Dos Santos C, et al. Antitumor and angiostatic activities of the antimicrobial peptide dermaseptin B2. PLoS One. 2012;7(9):e44351. PMID: 23028527.
