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AZD-3514

AZD-3514

Product ID A9713
Cas No. 1240299-33-5
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $105.00 In stock
5 mg $236.30 In stock
25 mg $892.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

AZD-3514 is an anticancer chemotherapeutic that downregulates androgen receptor levels and inhibits nuclear translocation of androgen receptors. This compound exhibits efficacy in prostate cancer subjects in clinical settings. In vivo, AZD-3514 suppresses tumor growth. AZD-3514 also inhibits seminal vesicle development in juvenile animal models.

Product Info

Cas No.

1240299-33-5

Purity

≥98%

Formula

C25H32F3N7O2

Formula Wt.

519.57

Chemical Name

1-{4-[2-(4-{1-[3-(Trifluoromethyl)-7,8-dihydro[1,2,4]triazolo[4,3-b]pyridazin-6-yl]-4-piperidinyl}phenoxy)ethyl]-1-piperazinyl}ethanone

IUPAC Name

1-{4-[2-(4-{1-[3-(Trifluoromethyl)-7,8-dihydro[1,2,4]triazolo[4,3-b]pyridazin-6-yl]-4-piperidinyl}phenoxy)ethyl]-1-piperazinyl}ethanone

Synonym

AZD3514

Solubility

DMSO 100 mg/mL Ethanol 100 mg/mL Water Insoluble

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

A9713 MSDS PDF

Info Sheet

A9713 Info Sheet PDF

References

Omlin A, Jones RJ, van der Noll R, et al. AZD3514, an oral selective androgen receptor down-regulator in patients with castration-resistant prostate cancer - results of two parallel first-in-human phase I studies. Invest New Drugs. 2015 Jun;33(3):679-90. PMID: 25920479.

Loddick SA, Ross SJ, Thomason AG, et al. AZD3514: a small molecule that modulates androgen receptor signaling and function in vitro and in vivo. Mol Cancer Ther. 2013 Sep;12(9):1715-27. PMID: 23861347.

Bradbury RH, Acton DG, Broadbent NL, et al. Discovery of AZD3514, a small-molecule androgen receptor downregulator for treatment of advanced prostate cancer. Bioorg Med Chem Lett. 2013 Apr 1;23(7):1945-8. PMID: 23466225.

Custom Order

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