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CYC-116

Product ID C9708
Cas No. 693228-63-6
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $107.40 In stock
25 mg $355.60 In stock
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  • Description
  • Product Info
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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

CYC-116 inhibits aurora kinases A and B (AurA, AurB), preventing mitotic spindle formation and proper completion of mitosis. This compound exhibits anticancer chemotherapeutic activity and is currently in clinical trials. CYC-116 inhibits proliferation of a variety of cancer cells.

Product Info

Cas No.

693228-63-6

Purity

≥98%

Formula

C18H20N6OS

Formula Wt.

368.46

IUPAC Name

4-methyl-5-[2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]-1,3-thiazol-2-amine

Solubility

DMSO 24 mg/mL warmed (65.13 mM) Water Insoluble Ethanol Insoluble

Appearance

Yellow Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

C9708 MSDS PDF

Info Sheet

C9708 Info Sheet PDF

References

Kamei H, Jackson RC, Zheleva D, et al. An integrated pharmacokinetic-pharmacodynamic model for an Aurora kinase inhibitor. J Pharmacokinet Pharmacodyn. 2010 Aug;37(4):407-34. PMID: 20694801.

Wang S, Midgley CA, Scaërou F, et al. Discovery of N-phenyl-4-(thiazol-5-yl)pyrimidin-2-amine aurora kinase inhibitors. J Med Chem. 2010 Jun 10;53(11):4367-78. PMID: 20462263.

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