PP-242

Product ID P6004

Cas No. 1092351-67-1

Purity ≥98%

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Description
Product Info
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References
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Description

PP-242 is an inhibitor of mTORC1/2 that displays anticancer chemotherapeutic and anti-metastatic activities. In various cellular models of acute leukemia, PP-242 inhibits cell proliferation. In animal models of pheochromocytoma, PP-242 induces apoptosis, upregulates expression of Bax, downregulates expression of Bcl-2, and decreases tumor volume. In gastric cancer cells, this compound also inhibits cell proliferation, migration, and invasion and suppresses tube formation and vascular invasion.

Product Info

Cas No.	1092351-67-1
Purity	≥98%
Formula	C₁₆H₁₆N₆O
Formula Wt.	308.34
IUPAC Name	2-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indol-5-ol
Synonym	Pp242, PP242, PP 242, Torkinib
Solubility	DMSO 61 mg/mL (197.83 mM) Ethanol 18 mg/mL (58.37 mM) Water Insoluble
Appearance	Tan to off white powder

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	P6004 MSDS PDF
Info Sheet	P6004 Info Sheet PDF

References

Shi F, Yang X, Gong Y, et al. The antileukemia roles of PP242 alone or in combination with daunorubicin in acute leukemia. Anticancer Drugs. 2015 Apr;26(4):410-21. PMID: 25535978.

Zhang X, Wang X, Qin L, et al. The dual mTORC1 and mTORC2 inhibitor PP242 shows strong antitumor activity in a pheochromocytoma PC12 cell tumor model. Urology. 2015 Jan;85(1):273.e1-7. PMID: 25440763.

Xing X, Zhang L, Wen X, et al. PP242 suppresses cell proliferation, metastasis, and angiogenesis of gastric cancer through inhibition of the PI3K/AKT/mTOR pathway. Anticancer Drugs. 2014 Nov;25(10):1129-40. PMID: 25035961.