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SB-939

SB-939

Product ID S0501
Cas No. 929016-96-6
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $117.20 In stock
5 mg $253.20 In stock
25 mg $759.70 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

SB939 (Pracinostat) is an inhibitor of class I, II, and IV histone deacetylases (HDACs) that exhibits anticancer chemotherapeutic, anti-parasitic, and antimalarial activities. SB939 decreases tumor growth in animal models of colorectal cancer. This compound also suppresses Plasmodium growth in vitro and in vivo and prevents malaria infection.

Product Info

Cas No.

929016-96-6

Purity

≥98%

Formula

C20H30N4O2

Formula Wt.

358.49

IUPAC Name

(2E)-3-{2-Butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide

Synonym

SB939, Pracinostat

Solubility

DMSO Solubility: 72 mg/mL (200.84 mM)

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

S0501 MSDS PDF

Info Sheet

S0501 Info Sheet PDF

References

Zorzi AP, Bernstein M, Samson Y, et al. A phase I study of histone deacetylase inhibitor, pracinostat (SB939), in pediatric patients with refractory solid tumors: IND203 a trial of the NCIC IND program/C17 pediatric phase I consortium. Pediatr Blood Cancer. 2013 Nov;60(11):1868-74. PMID: 23893953.

Sumanadasa SD, Goodman CD, Lucke AJ, et al. Antimalarial activity of the anticancer histone deacetylase inhibitor SB939. Antimicrob Agents Chemother. 2012 Jul;56(7):3849-56. PMID: 22508312.

Novotny-Diermayr V, Sangthongpitag K, et al. SB939, a novel potent and orally active histone deacetylase inhibitor with high tumor exposure and efficacy in mouse models of colorectal cancer. Mol Cancer Ther. 2010 Mar;9(3):642-52. PMID: 20197387.

Custom Order

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