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Floxuridine

Product ID F4557
Cas No. 50-91-9
Purity ≥98%
Product Unit SizeCostQuantityStock
100 mg $120.30 In stock
500 mg $305.00 In stock
1 g $502.60 In stock
Bulk Quote

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  • Description
  • Product Info
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  • References
  • Description
  • Product Info
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  • Downloads
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Description

Floxuridine is a fluorinated pyrimidine; it is an analog of 5-fluorouracil (5-FU). Floxuridine exhibits antiviral and anticancer chemotherapeutic activities. Floxuridine acts as an antimetabolite, inhibiting thymidylate synthase and inducing apoptosis in cancer cells. This compound also inhibits replication of dengue virus.

Product Info

Cas No.

50-91-9

Purity

≥98%

Formula

C9H11FN2O5

Formula Wt.

246.19

Chemical Name

2'-Deoxy-5-fluorouridine

IUPAC Name

5-fluoro-1-[(2R,4S, 5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione

Synonym

NSC-27640, FUDR

Melting Point

150-151°C

Solubility

Soluble in water.

Appearance

White Crystalline

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

F4557 MSDS PDF

Info Sheet

F4557 Info Sheet PDF

References

Fischer MA, Smith JL, Shum D, et al. Flaviviruses are sensitive to inhibition of thymidine synthesis pathways. J Virol. 2013 Sep;87(17):9411-9. PMID: 23824813.

Muñoz-Pinedo C, Robledo G, López-Rivas A. Thymidylate synthase inhibition triggers glucose-dependent apoptosis in p53-negative leukemic cells. FEBS Lett. 2004 Jul 16;570(1-3):205-10. PMID: 15251465.

Tobias SC, Borch RF. Synthesis and biological studies of novel nucleoside phosphoramidate prodrugs. J Med Chem. 2001 Dec 6;44(25):4475-80. PMID: 11728193.

Custom Order

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