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Statil

Product ID S7601
Cas No. 72702-95-5
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $68.10 In stock
25 mg $245.40 In stock
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  • Description
  • Product Info
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Description

Statil inhibits aldose reductase and exhibits anticancer activity; it is primarily used to study aldose reductase function in vitro. In breast cancer and lung cancer cells, statil inhibits cell growth and proliferation and induces apoptosis. Statil also enhances adipose-derived stem adipocyte differentiation.

Product Info

Cas No.

72702-95-5

Purity

≥98%

Formula

C17H12BrFN2O3

Formula Wt.

391.19

Chemical Name

2-[3-[(4-bromo-2-fluorophenyl)methyl]-4-oxophthalazin-1-yl]acetic acid

IUPAC Name

[3-(4-Bromo-2-fluorobenzyl)-4-oxo-3,4-dihydro-1-phthalazinyl]acetic acid

Synonym

Ponalrestat

Solubility

Soluble in DMSO

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

S7601 MSDS PDF

Info Sheet

S7601 Info Sheet PDF

References

Pastel E, Pointud JC, Loubeau G, et al. Aldose reductases influence prostaglandin F2α levels and adipocyte differentiation in male mouse and human species. Endocrinology. 2015 May;156(5):1671-84. PMID: 25730106.

Cao Z, Zhou B, Chen X, et al. Statil suppresses cancer cell growth and proliferation by the inhibition of tumor marker AKR1B10. Anticancer Drugs. 2014 Sep;25(8):930-7. PMID: 24800887.

El-Kabbani O, Ramsland P, Darmanin C, et al. Structure of human aldose reductase holoenzyme in complex with statil: an approach to structure-based inhibitor design of the enzyme. Proteins. 2003 Feb 1;50(2):230-8. PMID: 12486717.

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