Borrelidin

Name: Borrelidin
SKU: B5870
Availability: InStock

Product ID B5870

Cas No. 7184-60-3

Purity ≥99%

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Product Info
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References

Description

Borrelidin is a macrolide antibiotic initially produced by Streptomyces. Borrelidin exhibits anti-parasitic, antifungal, anticancer, and anti-angiogenic activities. This compound inhibits threonyl-tRNA synthetase/ligase, inhibiting growth and survival of Trypanosoma, Plasmodium, and Phytophthora. In acute lymphocytic leukemia (ALL) cells, borrelidin induces G1 phase cell cycle arrest, induces apoptosis, and inhibits proliferation. In endothelial cells, borrelidin inhibits formation of new capillary tubes and collapses pre-formed capillary tubes, inducing threonine- and caspase-dependent apoptosis.

Product Info

Cas No.	7184-60-3
Purity	≥99%
Formula	C₂₈H₄₃NO₆
Formula Wt.	489.64
IUPAC Name	2-(7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxo-1-oxacyclooctadeca-4,6-dien-2-yl)cyclopentane-1-carboxylic acid
Solubility	Soluble in ethanol, methanol (1 mg/ml), DMSO (1 mg/ml), DMF, and ethyl acetate
Appearance	Off white powder

Shipping and Storage

Store Temp	4°C
Ship Temp	Ambient

Downloads

MSDS	B5870 MSDS PDF
Info Sheet	B5870 Info Sheet PDF

References

Kalidas S, Cestari I, Monnerat S, et al. Genetic validation of aminoacyl-tRNA synthetases as drug targets in Trypanosoma brucei. Eukaryot Cell. 2014 Apr;13(4):504-16. PMID: 24562907.

Azcárate IG, Marín-García P, Camacho N, et al. Insights into the preclinical treatment of blood-stage malaria by the antibiotic borrelidin. Br J Pharmacol. 2013 Jun;169(3):645-58. PMID: 23488671.

Gao YM, Wang XJ, Zhang J, et al. Borrelidin, a potent antifungal agent: insight into the antifungal mechanism against Phytophthora sojae. J Agric Food Chem. 2012 Oct 3;60(39):9874-81. PMID: 22967236.

Habibi D, Ogloff N, Jalili RB, et al. Borrelidin, a small molecule nitrile-containing macrolide inhibitor of threonyl-tRNA synthetase, is a potent inducer of apoptosis in acute lymphoblastic leukemia. Invest New Drugs. 2012 Aug;30(4):1361-70. PMID: 21678129.

Otoguro K, Ui H, Ishiyama A, et al. In vitro and in vivo antimalarial activities of a non-glycosidic 18-membered macrolide antibiotic, borrelidin, against drug-resistant strains of Plasmodia. J Antibiot (Tokyo). 2003 Aug;56(8):727-9. PMID: 14563165.