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GDC-0941

GDC-0941

Product ID G124082
Cas No. 957054-30-7
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $81.70 In stock
25 mg $184.00 In stock
100 mg $511.10 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

GDC-0941 is a pan-PI3K inhibitor. When combined with paclitaxel, GDC-0941 exhibits antitumor activity in patients with locally recurrent or metastatic breast cancer. It also increases apoptosis in several cell lines of uveal melanoma in combination with the mTOR inhibitor everolimus.

Product Info

Cas No.

957054-30-7

Purity

≥98%

Formula

C23H27N7O3S2

Formula Wt.

513.64

IUPAC Name

2-(1H-Indazol-4-yl)-6-{[4-(methylsulfonyl)-1-piperazinyl]methyl}-4-(4-morpholinyl)thieno[3,2-d]pyrimidine

Synonym

GNE-0941, Pictilisib, Pictrelisib, RG7321

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

G124082 MSDS PDF

Info Sheet

G124082 Info Sheet PDF

References

Folkes A., Ahmadi K., et al. The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer. J Med Chem. 51(18):5522-32 (2008). PMID: 18754654.

Schoffski P., Cresta S., et al. A phase Ib study of pictilisib (GDC-0941) in combination with paclitaxel, with and without bevacizumab or trastuzumab, and with letrozole in advanced breast cancer. Breast Cancer Res. 20(1):109 (2018). PMID: 30185228.

Amirouchene-Angelozzi N., Frisch-Dit-Leitz E., et al. The mTOR inhibitor Everolimus synergizes with the PI3K inhibitor GDC0941 to enhance anti-tumor efficacy in uveal melanoma. Oncotarget. 7(17):23633-46 (2016). PMID: 26988753.

Custom Order

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