LKT Labs

Biochemicals for Life Science Research

Norfloxacin

Norfloxacin

Product ID N5768
Cas No. 70458-96-7
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $37.10 In stock
5 g $83.40 In stock
10 g $143.40 In stock
50 g $510.30 In stock
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Description

Norfloxacin is a first generation fluoroquinolone antibiotic that exhibits antibacterial, anti-inflammatory, and anticancer activities. Norfloxacin inhibits DNA gyrase and topoisomerase IV; it is clinically used to treat urinary tract infections and prostatitis. In neutrophils from cirrhotic subjects, norfloxacin increases expression of IL-10 and heme oxygenase 1 (HO-1) and decreases expression of pro-inflammatory cytokines. Additionally, when complexed with gold(III), norfloxacin binds DNA and inhibits cellular proliferation in several cancer cell lines.

Product Info

Cas No.

70458-96-7
Purity

≥98%
Formula

C16H18FN3O3

Formula Wt.

319.33
Chemical Name

1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid  

IUPAC Name

1-ethyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid
Synonym

Baccidal, Sebercim
Melting Point

227-228°C

Solubility

Soluble in water (0.28 mg/mL), methanol (1 mg/mL), ethanol (1.9 mg/mL).
Appearance

Yellowish white crystal powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

N5768 MSDS PDF
Info Sheet

N5768 Info Sheet PDF

References

Gouvea LR, Garcia LS, Lachter DR, et al. Atypical fluoroquinolone gold(III) chelates as potential anticancer agents: relevance of DNA and protein interactions for their mechanism of action. Eur J Med Chem. 2012 Sep;55:67-73. PMID: 22835721.

Gómez-Hurtado I, Zapater P, Bellot P, et al. Interleukin-10-mediated heme oxygenase 1-induced underlying mechanism in inflammatory down-regulation by norfloxacin in cirrhosis. Hepatology. 2011 Mar;53(3):935-44. PMID: 21374664.

PadeÄ­skaia EN. Norfloxacin: more than 20 years of clinical use, the results and place among fluoroquinolones in modern chemotherapy for infections. Antibiot Khimioter. 2003;48(9):28-36. PMID: 15002177.

Drlica K, Zhao X. DNA gyrase, topoisomerase IV, and the 4-quinolones. Microbiol Mol Biol Rev. 1997 Sep;61(3):377-92. PMID: 9293187.

Ho YB, Zakaria MP, Latif PA, Saari N. Occurrence of veterinary antibiotics and progesterone in broiler manure and agricultural soil in Malaysia. Sci Total Environ. 2014 Aug 1;488-489:261-267. PMID: 24836135.

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