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AR-A014418

AR-A014418

Product ID A6800
Cas No. 487021-52-3
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $72.00 In stock
5 mg $135.00 In stock
10 mg $211.10 In stock
25 mg $421.90 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

AR-A014418 is an inhibitor of GSK-3β that exhibits anticancer, analgesic, cognition enhancing, neuroprotective, and anti-inflammatory activities. AR-A014418 decreases cell viability and downregulates expression of splicing factors, Bcl-2, Bcl-xl, survivin, and MCL-1 in glioma cells. In models of neuropathic pain, AR-A014418 inhibits thermal hyperalgesia and mechanical allodynia, potentially through suppressing expression of glutamate transporter GLT-1. This compound also inhibits the development of learning and memory deficits in animal models of diabetes. In spinal cord injury models, AR-A014418 prevents mitochondrial apoptosis and decreases levels of pro-inflammatory cytokines.

Product Info

Cas No.

487021-52-3

Purity

≥98%

Formula

C12H12N4O4S

Formula Wt.

308.31

IUPAC Name

1-(4-Methoxybenzyl)-3-(5-nitro-1,3-thiazol-2-yl)urea

Synonym

GSK-3β Inhibitor VIII

Solubility

DMSO Solubility: 61 mg/mL (197.85 mM)

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

A6800 MSDS PDF

Info Sheet

A6800 Info Sheet PDF

References

Yadav AK, Vashishta V, Joshi N, et al. AR-A 014418 Used against GSK3beta Downregulates Expression of hnRNPA1 and SF2/ASF Splicing Factors. J Oncol. 2014;2014:695325. PMID: 24550987.

Weng HR, Gao M, Maixner DW. Glycogen synthase kinase 3 beta regulates glial glutamate transporter protein expression in the spinal dorsal horn in rats with neuropathic pain. Exp Neurol. 2014 Feb;252:18-27. PMID: 24275526.

King MR, Anderson NJ, Guernsey LS, et al. Glycogen synthase kinase-3 inhibition prevents learning deficits in diabetic mice. J Neurosci Res. 2013 Apr;91(4):506-14. PMID: 23362012.

Tunçdemir M, Yıldırım A, Karaoğlan A, et al. AR-A014418 as a glycogen synthase kinase-3 inhibitor: anti-apoptotic and therapeutic potential in experimental spinal cord injury. Neurocirugia (Astur). 2013 Jan-Feb;24(1):22-32. PMID: 23116585.

Custom Order

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