• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
SAG Dihydrochloride

SAG Dihydrochloride

Product ID S0225
Cas No. 364590-63-6
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $78.80 In stock
5 mg $236.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

SAG is a Smoothened (Smo) agonist primarily used in research models to study Hedgehog signaling pathways. In vitro, SAG stimulates osteoblastic differentiation of mesenchymal stem cells and enhances proliferation of pulmonary arterial smooth muscle cells. SAG also increases expression of Patched and efflux of cholesterol. In vivo, this compound exhibits neuroprotective activity, preventing glucocorticoid-induced neurotoxicity.

Product Info

Cas No.

364590-63-6

Purity

≥98%

Formula

C28H29Cl2N3OS

Formula Wt.

617.02

Chemical Name

SAG Dihydrochloride

IUPAC Name

3-chloro-N-[4-(methylamino)cyclohexyl]-N-[(3-pyridin-4-ylphenyl)methyl]-1-benzothiophene-2-carboxamide;2 hydrochloride

Synonym

Smoothened agonist hydrochloride

Solubility

Soluble in water or DMSO.

Appearance

Light yellow solid.

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

S0225 MSDS PDF

Info Sheet

S0225 Info Sheet PDF

References

Huang JG, Shen CB, Wu WB, et al. Primary cilia mediate sonic hedgehog signaling to regulate neuronal-like differentiation of bone mesenchymal stem cells for resveratrol induction in vitro. J Neurosci Res. 2014 May;92(5):587-96. PMID: 24464877.

Heine VM, Griveau A, Chapin C, et al. A small-molecule smoothened agonist prevents glucocorticoid-induced neonatal cerebellar injury. Sci Transl Med. 2011 Oct 19;3(105):105ra104. PMID: 22013124.

Bidet M, Joubert O, Lacombe B, et al. The hedgehog receptor patched is involved in cholesterol transport. PLoS One. 2011;6(9):e23834. PMID: 21931618.

Wang G, Zhang Z, Xu Z, et al. Activation of the sonic hedgehog signaling controls human pulmonary arterial smooth muscle cell proliferation in response to hypoxia. Biochim Biophys Acta. 2010 Dec;1803(12):1359-67. PMID: 20840857.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • O1177

    n-Octyl-3,4-Dimethylcaffeate

    Methylated derivative of n-octyl-caffeate.

    ≥98%
  • B3210

    R-Bicalutamide

    AR antagonist.

    ≥98%
  • R1217

    RDEA119

    MEK1/2 inhibitor.

    ≥98%
  • S8145

    Sulindac

    NSAID; COX-1/2 and PDE inhibitor.

    ≥99%
  • O938565

    6-Oxodocetaxel

    Docetaxel impurity

    ≥98%
  • M185777

    4-(Methylsulfinyl) butylamine

    ≥99%
  • C2957

    Cholesterol

    Endogenous sterol component of animal cell memb...

    ≥97%
  • S0245

    Salmeterol

    β2-adrenergic agonist.

    ≥98%
  • V0148

    Valproic Acid

    T-type Ca2+ and voltage-gated Na+ channel block...

    ≥98%
  • O7377

    Osthole

    O-methylated coumarin; Ca2+ channel blocker.

    ≥98%
  • A5313

    Andrographolide

    Labdane diterpene found in Andrographis; RLR (R...

    ≥98%
  • T0107

    Xylosyltaxol C

    Taxane found in species of Taxus; potential mic...

    ≥90%
  • A1592

    ADX-47273

    mGluR5 positive modulator.

    ≥98%
  • P1765

    Peptide Standard 1

    For use in amino acid analysis.

    ≥95%
  • P9668

    Pyrantel Pamoate

    Mixture of pyrantel, a thiophene, and pamoic ac...

    ≥98%
  • S8098

    SU-1498

    Tyrphostin; VEGFR inhibitor.

    ≥99%
  • P4560

    Proteolipid Protein (139-151)

    Immunodominant peptide fragment of PLP, used to...

    ≥95%
  • T6934

    Trimebutine Maleate

    L-type Ca2+ channel blocker, BK K+ channel modu...

    ≥96%
  • G3353

    Ginkgolic Acid (15:1)

    Found in Ginkgo; HIV protease and fatty acid sy...

    ≥98%
  • M1875

    S-(N-Methylsulfinylbutylthiocarbamoyl)-glutathione

    Glutathione-sulforaphane conjugate, antioxidant...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only