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Atorvastatin Calcium Trihydrate

Atorvastatin Calcium Trihydrate

Product ID A7658
Cas No. 344423-98-9
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $71.50 In stock
50 mg $207.50 In stock
100 mg $321.90 In stock
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
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Description

Atorvastatin exhibits anti-hyperlipidemic, anti-inflammatory, anti-fibrotic, and cardioprotective activities. Atorvastatin acts as an inhibitor of HMG-CoA reductase, preventing cholesterol synthesis and decreasing levels of total cholesterol, triglycerides, and LDL and increasing levels of HDL. In animal models of renal ischemia/perfusion, atorvastatin decreases expression of toll-like receptor 4 (TLR4) an hmgb1, decreasing oxidative stress and inflammation. Additionally, atorvastatin inhibits left ventricular hypertrophy and cardiac fibrosis and decreases expression of HSP47 in animal models of heart failure.

Product Info

Cas No.

344423-98-9

Purity

≥98%

Formula

(C33H34FN2O5)2Ca • 3H2O

Formula Wt.

1209.39

Chemical Name

(βR,δR)-2-(4-Fluorophenyl)-β,δ-dihydroxy-5-(1- methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid

IUPAC Name

calcium;7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2- ylpyrrol-1-yl]-3,5-dihydroxyheptanoate;trihydrate

Synonym

Atorvastatin Calcium Salt, Lipitor, Sortis: Torvast, Totalip, Xarator

Melting Point

159-161°C

Solubility

Soluble in methanol. Very slightly soluble in water and acetonitrile. Slightly soluble in ethanol. DMSO (10 mg/ml)

Appearance

Off White Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

A7658 MSDS PDF

Info Sheet

A7658 Info Sheet PDF

References

Cai J, Yu X, Zhang B, et al. Atorvastatin improves survival of implanted stem cells in a rat model of renal ischemia-reperfusion injury. Am J Nephrol. 2014;39(6):466-75. PMID: 24854145.

Akahori H, Tsujino T, Naito Y, et al. Atorvastatin ameliorates cardiac fibrosis and improves left ventricular diastolic function in hypertensive diastolic heart failure model rats. J Hypertens. 2014 Jul;32(7):1534-41. PMID: 24759122.

Lea AP, McTavish D. Atorvastatin. A review of its pharmacology and therapeutic potential in the management of hyperlipidaemias. Drugs. 1997 May;53(5):828-47. PMID: 9129869.

Izumi S, Nozaki Y, Maeda K, et al. Investigation of the impact of substrate selection on in vitro organic anion transporting polypeptide 1B1 inhibition profiles for the prediction of drug-drug interactions. Drug Metab Dispos. 2015 Feb;43(2):235-247. PMID: 25414411.

Custom Order

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