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Olopatadine hydrochloride is an antihistamine clinically used to treat allergic rhinitis and allergic conjunctivitis. This compound acts as a mast cell stabilizer, preventing histamine and TNF-α release from mast cells. Olopatadine is also an antagonist at histamine H1/2/3 receptors, although it is selective primarily for H1 receptors over other subtypes. Additionally, olopatadine suppresses allergy-related increases in substance P, NGF, and VEGF.
| Cas No. | 140462-76-6 |
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| Purity | ≥99% |
| Formula | C21H23NO3 • HCl |
| Formula Wt. | 373.87 |
| IUPAC Name | 2-[(11Z)-11-[3-(dimethylamino)propylidene]-6H-benzo[c][1]benzoxepin-2-yl]acetic acid;hydrochloride InChI: InChI=1S/C21H23NO3.ClH/c1-22(2)11-5-8-18-17-7-4-3-6-16(17)14-25-20-10-9-15(12-19(18)20)13-21(23)24;/h3-4,6-10,12H,5,11,13-14H2,1-2H3,(H,23,24);1H/b18-8-; |
| Melting Point | 245-248°C |
| Solubility | H2O: ≥20 mg/mL DMSO: 37mg/ml |
| Appearance | White powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Tamura T. Olopatadine ophthalmic solution suppresses substance P release in the conjunctivitis models. Asia Pac Allergy. 2012 Apr;2(2):115-21. PMID: 22701861.
Tamura T. Investigation of the antiallergic activity of olopatadine on rhinitis induced by intranasal instillation of antigen in sensitized rats using thermography. Asia Pac Allergy. 2011 Oct;1(3):138-44. PMID: 22053310.
Roland PS, Ryan MW, Wall GM. Olopatadine nasal spray for the treatment of seasonal allergic rhinitis in patients aged 6 years and older. Expert Opin Pharmacother. 2010 Jun;11(9):1559-67. PMID: 20482305.
Leonardi A, Quintieri L. Olopatadine: a drug for allergic conjunctivitis targeting the mast cell. Expert Opin Pharmacother. 2010 Apr;11(6):969-81. PMID: 20307221.
Sharif NA, Xu SX, Yanni JM. Olopatadine (AL-4943A): ligand binding and functional studies on a novel, long acting H1-selective histamine antagonist and anti-allergic agent for use in allergic conjunctivitis. J Ocul Pharmacol Ther. 1996 Winter;12(4):401-7. PMID: 8951676.
Yanni JM, Stephens DJ, Miller ST, et al. The in vitro and in vivo ocular pharmacology of olopatadine (AL-4943A), an effective anti-allergic/antihistaminic agent. J Ocul Pharmacol Ther. 1996 Winter;12(4):389-400. PMID: 8951675.
