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Temsirolimus

Product ID T176503
Cas No. 162635-04-3
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $100.10 In stock
25 mg $412.00 In stock
100 mg $918.20 In stock
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Description

Temsirolimus is an analog of rapamycin found to be active against several cancer types. Like rapamycin, temsirolimus is also an mTOR inhibitor. Temsirolimus has shown activity against brain, rhabdomyosarcoma, multiple myeloma, breast, tuberous sclerosis complex, acute lymphoblastic leukemia, pancreatic, prostate, neuroendocrine, renal cell carcinoma, neuroblastoma, and several other cancer types. When treated with temsirolimus, oral squamous cell carcinoma cell’s proliferation and migration were inhibited in vitro and growth of xenografts was suppressed in vivo. Furthermore, in animal models of Parkinson’s disease, treatment with temsirolimus led to increased expression of markers including tyrosine hydroxylase and dopamine transporter and also decreased the upregulation of alpha-synuclein in the substantia nigra after MPTP-induced neurotoxicity. Temsirolimus was found to modulate the autophagic process and the neuroinflammatory pathway in Parkinson’s disease, demonstrating a neuroprotective effect.

Product Info

Cas No.

162635-04-3

Purity

≥98%

Formula

C56H87NO16

Formula Wt.

1030.30

Chemical Name

Temsirolimus

IUPAC Name

[(1~{R},2~{R},4~{S})-4-[(2~{R})-2-[(1~{R},9~{S},12~{S},15~{R},16~{E},18~{R},19~{R},21~{R},23~{S},24~{Z},26~{E},28~{E},30~{S},32~{S},35~{R})-1,18-dihydroxy-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-2,3,10,14,20-pentaoxo-11,36-dioxa-4-azatricyclo[30.3.1.0^{4,9}]hexatriaconta-16,24,26,28-tetraen-12-yl]propyl]-2-methoxycyclohexyl] 3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate

Synonym

CCI-779; NSC 683864; rapamycin, 42-(3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate)

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

T176503 MSDS PDF

Info Sheet

T176503 Info Sheet PDF

References

Geoerger B, Kerr K, Tang CB, et al. Antitumor activity of the rapamycin analog CCI-779 in human primitive neuroectodermal tumor/medulloblastoma models as single agent and in combination chemotherapy. Cancer Res. 2001 Feb 15;61(4):1527-1532. PMID: 11245461.

Gera JF, Mellinghoff IK, Shi Y, et al. AKT activity determines sensitivity to mammalian target of rapamycin (mTOR) inhibitors by regulating cyclin D1 and c-myc expression. J Biol Chem. 2004 Jan 23;279(4):2737-2746. PMID: 14576155.

Okui T, Shimo T, Fukazawa T, et al. Antitumor effect of temsirolimus against oral squamous cell carcinoma associated with bone destruction. Mol Cancer Ther. 2010 Nov;9(11):2960-2969. PMID: 20858724.

Siracusa R, Paterniti I, Cordaro M, et al. Neuroprotective effects of temsirolimus in animal models of Parkinson’s disease. Mol Neurobiol. 2018 Mar;55(3):2403-2419. PMID: 28357809.

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