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Resiquimod

Resiquimod

Product ID R183731
Cas No. 144875-48-9
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $60.10 In stock
10 mg $105.30 In stock
25 mg $217.90 In stock
50 mg $375.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Resiquimod is an imidazoquinoline compound that is a TLR7/8 agonist. Resiquimod has been shown to activate dendritic cells in both healthy and inflamed skin, making it effective to induce regression of cutaneous T-cell lymphoma lesions. BALB/c mice treated with resiquimod showed high levels of resistance against parasitic infection. Furthermore, resiquimod has been shown to produce cardioprotective effects in anoxia-regeneration injuries of neonatal cardiomyocytes.

Product Info

Cas No.

144875-48-9

Purity

≥98%

Formula

C17H22N4O2

Formula Wt.

314.39

Chemical Name

1-[4-amino-2-(ethoxymethyl)imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol

IUPAC Name

1-[4-Amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methyl-2-propanol

Synonym

R-848, R848, S28463, alpha-dimethyl-1H-imidazo(4,5-c)quinoline-1-ethanol.

Solubility

Soluble in DMSO (100 mM), ethanol (50 mM), 100% or 5% methanol, and dichloromethane. Insoluble in water.

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

R183731 MSDS PDF

Info Sheet

R183731 Info Sheet PDF

References

Rook AH, Gelfand JM, Wysocka M, et al. Topical resiquimod can induce disease regression and enhance T-cell effector functions in cutaneous T-cell lymphoma. Blood. 2015 Sep 17;126(12):1452-1461. PMID: 26228486.

Craft N, Birnbaum R, Quanquin N, et al. Topical resiquimod protects against visceral infection with Leishmania infantum chagasi in mice. Clin Vaccine Immunol. 2014 Sep;21(9):1314-1322. PMID: 25030052.

Wang YY, Liu S, Lian F, et al. Toll-like receptor 7/8 agonist resiquimod induces late preconditioning in neonatal cardiac myocytes. Acta Pharmacol Sin. 2011 May;32(5):565-572. PMID: 21516132.

Custom Order

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