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MK-5108 Hydrochloride

MK-5108 Hydrochloride

Product ID M400005
Cas No. 1010085-13-8
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $61.40 In stock
5 mg $184.00 In stock
10 mg $272.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

MK-5108 inhibits aurora kinase A (AurA) preventing mitotic spindle formation and proper completion of mitosis. MK-5108 exhibits anticancer chemotherapeutic activity. In uterine leiomyosarcoma cells, MK-5108 inhibits proliferation and induces apoptosis; in animal models, this compound decreases tumor number and size. Additionally, in epithelial ovarian cancer cells, MK-5108 induces polyploidy and cell cycle arrest, and inhibits activation of NF-κB.

Product Info

Cas No.

1010085-13-8

Purity

≥98%

Formula

C22H21ClFN3O3S • HCl

Formula Wt.

498.39

Chemical Name

MK-5108 Hydrochloride

IUPAC Name

4-(3-chloro-2-fluorophenoxy)-1-[[6-(1,3-thiazol-2-ylamino)pyridin-2-yl]methyl]cyclohexane-1-carboxylic acid;hydrochloride

Synonym

MK5108, VX-689, VX689

Solubility

Solubility in DMSO-12 mg/mL

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

M400005 MSDS PDF

Info Sheet

M400005 Info Sheet PDF

References

Shan W, Akinfenwa PY, Savannah KB, et al. A small-molecule inhibitor targeting the mitotic spindle checkpoint impairs the growth of uterine leiomyosarcoma. Clin Cancer Res. 2012 Jun 15;18(12):3352-65. PMID: 22535157.

Chefetz I, Holmberg JC, Alvero AB, et al. Inhibition of Aurora-A kinase induces cell cycle arrest in epithelial ovarian cancer stem cells by affecting NFĸB pathway. Cell Cycle. 2011 Jul 1;10(13):2206-14. PMID: 21623171.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
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