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Valinomycin

Product ID V0145
Cas No. 2001-95-8
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $41.00 In stock
10 mg $61.50 In stock
25 mg $136.40 In stock
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  • Product Info
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  • References
  • Description
  • Product Info
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Description

Valinomycin is a peptide antibiotic originally produced by Streptomyces. Valinomycin displays antibacterial efficacy by inhibiting growth of Streptomyces and Clostridium. Valinomycin is a neutral ionophore that transports K+ ions through cellular membranes, altering the electrochemical gradient. In vitro, valinomycin induces mitochondrial damage, oxidative stress, and caspase expression.

Product Info

Cas No.

2001-95-8

Purity

≥98%

Formula

C54H90N6O18

Formula Wt.

1111.32

IUPAC Name

6,18,30-trimethyl-3,9,12,15,21,24,27,33,36-nona(propan-2-yl)-1,7,13,19, 25,31-hexaoxa-4,10,16,22,28,34-hexazacyclohexatriacontane-2,5,8,11,14, 17,20,23,26,29,32,35-dodecone

Synonym

Valinomicin

Melting Point

190°C

Solubility

Insoluble in water. Soluble in ether, benzene, chloroform and acetone.

Appearance

White Solid

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

V0145 MSDS PDF

Info Sheet

V0145 Info Sheet PDF

References

Li R, El-Mallahk RS. A novel evidence of different mechanisms of lithium and valproate neuroprotective action on human SY5Y neuroblastoma cells: caspase-3 dependency. Neurosci Lett. 2000 Nov 24;294(3):147-50. PMID: 11072136.

Gad SC, Reilly C, Siino K, et al. Thirteen cationic ionophores: their acute toxicity, neurobehavioral and membrane effects. Drug Chem Toxicol. 1985;8(6):451-68. PMID: 4092618.

Seshachalam D, Frahm DH, Ferraro FM. Cation reversal of inhibition of growth by valinomycin in Streptococcus pyogenes and Clostridium sporogenes. Antimicrob Agents Chemother. 1973 Jan;3(1):63-7. PMID: 4208280.

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