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Etoricoxib

Product ID E7858
Cas No. 202409-33-4
Purity ≥99%
Product Unit SizeCostQuantityStock
5 mg $64.70 In stock
25 mg $94.20 In stock
100 mg $353.20 In stock
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  • Product Info
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  • Description
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Description

Etoricoxib is a non-steroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic, antioxidative, anticancer, anti-angiogenic, and chemopreventive activities. Etoricoxib inhibits COX-2; it also increases activity of superoxide dismutase, catalase, glutathione reductase, and glutathione transferase in animal models. Etoricoxib downregulates expression of matrix metalloproteinases 2 and 9 (MMP2/9), COX-2, MPC-1, VEGF, and MIP-1β in vivo. In other animal models, etoricoxib decreases aberrant crypt foci and lesion formation, suppressing colon carcinogenesis.

Product Info

Cas No.

202409-33-4

Purity

≥99%

Formula

C18H15ClN2O2S

Formula Wt.

358.84

IUPAC Name

5-chloro-2-(6-methylpyridin-3-yl)-3-(4-methylsulfonylphenyl)pyridine

Solubility

freely soluble in methanol, tetrahydrofuran, dimethyl sulfoxide, methyl ethyl ketone, dimethyl formamide, and chloroform. Etoricoxib is soluble in isopropyl acetate, ethanol and toluene, sparingly soluble in 2-propanol, and practically insoluble in water.

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

E7858 MSDS PDF

Info Sheet

E7858 Info Sheet PDF

Brochures

NSAID Flyer

References

Nadda N, Vaish V, Setia S, et al. Angiostatic role of the selective cyclooxygenase-2 inhibitor etoricoxib (MK0663) in experimental lung cancer. Biomed Pharmacother. 2012 Sep;66(6):474-83. PMID: 22681911.

Sharma P, Kaur J, Sanyal SN. Effect of etoricoxib, a cyclooxygenase-2 selective inhibitor on aberrant crypt formation and apoptosis in 1,2 dimethyl hydrazine induced colon carcinogenesis in rat model. Nutr Hosp. 2010 Jan-Feb;25(1):39-48. PMID: 20204254.

Kanwar SS, Vaiphei K, Nehru B, et al. Antioxidative effects of nonsteroidal anti-inflammatory drugs during the initiation stages of experimental colon carcinogenesis in rats. J Environ Pathol Toxicol Oncol. 2008;27(2):89-100. PMID: 18540845.

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