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Cyclosporin A

Product ID C9611
Cas No. 59865-13-3
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $41.00 In stock
50 mg $61.50 In stock
100 mg $88.60 In stock
500 mg $238.60 In stock
1 g $340.70 In stock
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  • Product Info
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  • Description
  • Product Info
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Description

Cyclosporin A is a cyclic peptide that exhibits immunosuppressive activity. Cyclosporin A is clinically used to prevent rejection in organ transplants and to treat or prevent graft-versus-host disease (GvHD). Cyclosporin A binds cyclophilin, inhibiting calcineurin and decreasing levels of IL-2 and activated T cells. Cyclosporin A also shows benefit in the treatment of traumatic brain injury.

Product Info

Cas No.

59865-13-3

Purity

≥98%

Formula

C62H111N11O12

Formula Wt.

1202.61

IUPAC Name

(3S,6S,9S,12R,15S,18S,21R,24S,30S)-30-ethyl-33-[(E,1R, 2R)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,22,25, 28-decamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1, 4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17, 20,23,26,29,32-undecone

Synonym

Cyclosporine, Ciclosporin, Sandimmun, Neoral

Melting Point

148-151°C

Solubility

Soluble in methanol, ethanol, acetone, ether or chloroform. Also soluble in DMSO (>50 mg/mL). Very slightly soluble in water.

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

C9611 MSDS PDF

Info Sheet

C9611 Info Sheet PDF

References

Lulic D, Burns J, Bae EC, et al. A review of laboratory and clinical data supporting the safety and efficacy of cyclosporin A in traumatic brain injury. Neurosurgery. 2011 May;68(5):1172-86. PMID: 21307793.

Reynolds NJ, Al-Daraji WI. Calcineurin inhibitors and sirolimus: mechanisms of action and applications in dermatology. Clin Exp Dermatol. 2002 Oct;27(7):555-61. PMID: 12464150.

Handschumacher RE, Harding MW, Rice J, et al. Cyclophilin: a specific cytosolic binding protein for cyclosporin A. Science. 1984 Nov 2;226(4674):544-7. PMID: 6238408.

Koseki N, Deguchi J, Yamashita A, et al. Establishment fo a novel experimental protocol for drug-induced seizure liability screening based on a locomotor activity assay in zebrafish. J Toxicol Sci. 2014 Aug;39(4):579-600. PMID: 25056783.

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