2’,3’-cGAMP Sodium Salt

Name: 2’,3’-cGAMP Sodium Salt
SKU: G016499
Availability: InStock

Product ID G016499

Cas No. 1441190-66-4

Purity ≥99%

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Description

2’,3’-cGAMP sodium salt is a mammalian, noncanonical cyclic dinucleotide with a higher binding potency for human STING than 2’2’-cGAMP and 3’3’-cGAMP. The enzyme cGAMP synthase initiates cGAMP production in the presence of cytosolic DNA, triggering an immune response through the STING pathway. Addition of 2’,3’-cGAMP to vaccination of porcine reproductive and respiratory syndrome virus virus-like particles in piglets resulted in enhanced virus replication but did not increase disease severity.

Product Info

Cas No.	1441190-66-4
Purity	≥99%
Formula	C₂₀H₂₂N₁₀O₁₃P₂ • 2Na
Formula Wt.	718.38
IUPAC Name	disodium;2-amino-9-[(1R,6R,8R,9R,10S,15R,17R,18R)-8-(6-aminopurin-9-yl)-9,18-dihydroxy-3,12-dioxido-3,12-dioxo-2,4,7,11,13,16-hexaoxa-3λ5,12λ5-diphosphatricyclo[13.2.1.06,10]octadecan-17-yl]-1H-purin-6-one
Synonym	2’,3’-Cyclic GMP-AMP Sodium Salt; AKOS032949718; 2',3'-Cyclic guanosine monophosphate-adenosine monophosphate sodium salt

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	G016499 MSDS PDF
Info Sheet	G016499 Info Sheet PDF

References

Wu, J., Sun, L., et al. Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science. 339(6121), 826-830 (2013). PMID: 23258412.

Zhang, X., Shi, H., et al. Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING. Mol Cell. 51(2), 226-235 (2013). PMID: 23747010.

Van Noort A, Nelsen A, Pillatzki AE, et al. Intranasal immunization of pigs with porcine reproductive and respiratory syndrome virus-like particles plus 2’,3’-cGAMP VacciGrade adjuvant exacerbates viremia after virus challenge. Virol J. 2017 Apr 12;14(1):76. PMID: 28403874.