• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register

2’,3’-cGAMP Sodium Salt

Product ID G016499
Cas No. 1441190-66-4
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $340.00 In stock
5 mg $1,211.30 In stock
Bulk Quote
Add to Wishlist

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

2’,3’-cGAMP sodium salt is a mammalian, noncanonical cyclic dinucleotide with a higher binding potency for human STING than 2’2’-cGAMP and 3’3’-cGAMP. The enzyme cGAMP synthase initiates cGAMP production in the presence of cytosolic DNA, triggering an immune response through the STING pathway. Addition of 2’,3’-cGAMP to vaccination of porcine reproductive and respiratory syndrome virus virus-like particles in piglets resulted in enhanced virus replication but did not increase disease severity.

Product Info

Cas No.

1441190-66-4

Purity

≥99%

Formula

C20H22N10O13P2 • 2Na

Formula Wt.

718.38

IUPAC Name

disodium;2-amino-9-[(1R,6R,8R,9R,10S,15R,17R,18R)-8-(6-aminopurin-9-yl)-9,18-dihydroxy-3,12-dioxido-3,12-dioxo-2,4,7,11,13,16-hexaoxa-3λ5,12λ5-diphosphatricyclo[13.2.1.06,10]octadecan-17-yl]-1H-purin-6-one

Synonym

2’,3’-Cyclic GMP-AMP Sodium Salt; AKOS032949718; 2',3'-Cyclic guanosine monophosphate-adenosine monophosphate sodium salt   

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

G016499 MSDS PDF

Info Sheet

G016499 Info Sheet PDF

References

Wu, J., Sun, L., et al. Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science. 339(6121), 826-830 (2013). PMID: 23258412.

Zhang, X., Shi, H., et al. Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING. Mol Cell. 51(2), 226-235 (2013). PMID: 23747010.

Van Noort A, Nelsen A, Pillatzki AE, et al. Intranasal immunization of pigs with porcine reproductive and respiratory syndrome virus-like particles plus 2’,3’-cGAMP VacciGrade adjuvant exacerbates viremia after virus challenge. Virol J. 2017 Apr 12;14(1):76. PMID: 28403874.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2023 LKT Laboratories, All Rights Reserved - Products for research use only