Clofibric Acid

Name: Clofibric Acid
SKU: C4556
Availability: InStock

Product ID C4556

Cas No. 882-09-7

Purity ≥98%

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Product Info
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References

Description

Clofibric acid is a metabolite of clofibrate that activates PPARα receptors and inhibits auxin activity, exhibiting anti-hyperlipidemic, anti-angiogenic, anticancer chemotherapeutic, and herbicidal activity. Clofibric acid alters plant hormone activity and is used as a plant growth regulator. Clofibric acid also inhibits phosphatidylethanolamine synthesis, decreasing production of cholesterol and activity of HMG-CoA reductase and ACAT. Additionally, clofibric acid suppresses production of prostaglandin E2 (PGE2) and VEGF, decreases vessel density, and inhibits tumor growth in animal models of ovarian cancer.

Product Info

Cas No.	882-09-7
Purity	≥98%
Formula	C₁₀H₁₁ClO₃
Formula Wt.	214.65
Chemical Name	2-(4-Chlorophenoxy)-2-methylpropanoic acid
IUPAC Name	2-(4-chlorophenoxy)-2-methylpropanoic acid
Synonym	Chlorfibrinic acid, Arteriohom, Regulipid
Melting Point	118-119°C
Appearance	Light Yellow Fine Crystalline Powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	C4556 MSDS PDF
Info Sheet	C4556 Info Sheet PDF

References

Yokoyama Y, Xin B, Shigeto T, et al. Clofibric acid, a peroxisome proliferator-activated receptor alpha ligand, inhibits growth of human ovarian cancer. Mol Cancer Ther. 2007 Apr;6(4):1379-86. PMID: 17431116.

Nishimaki-Mogami T, Suzuki K, Okochi E, et al. Bezafibrate and clofibric acid are novel inhibitors of phosphatidylcholine synthesis via the methylation of phosphatidylethanolamine. Biochim Biophys Acta. 1996 Nov 11;1304(1):11-20. PMID: 8944746.

Haughom B, Spydevold O. The mechanism underlying the hypolipemic effect of perfluorooctanoic acid (PFOA), perfluorooctane sulphonic acid (PFOSA) and clofibric acid. Biochim Biophys Acta. 1992 Sep 22;1128(1):65-72. PMID: 1327145.