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(S,S)-ICG-001

(S,S)-ICG-001

Product ID I088240
Cas No. 847591-62-2
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $99.80 In stock
5 mg $262.50 In stock
25 mg $787.50 In stock
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

(S,S)-ICG-001 is an inhibitor of Wnt/β-catenin signaling. Treatment of nasopharyngeal carcinoma cells with ICG-001 led to reduced capability of the cells to adhere to extracellular matrix and capillary endothelial cells, and reduced tumor cell migration and invasion. In high-fat diet mice, treatment improved renal function, inhibited proinflammatory cytokines expression, reduced proteinuria and alleviated podocyte injury. Treatment of cancer stem-like cells with both ICG-001 and metformin together led to decreased expression of CSC markers and promoted autophagy and apoptosis synergistically.

Product Info

Cas No.

847591-62-2

Purity

≥98%

Formula

C33H32N4O4

Formula Wt.

548.63

IUPAC Name

(6S,9aS)-N-benzyl-6-[(4-hydroxyphenyl)methyl]-8-(naphthalen-1-ylmethyl)-4,7-dioxo-3,6,9,9a-tetrahydro-2H-pyrazino[1,2-a]pyrimidine-1-carboxamide

Synonym

beta-Catenin Inhibitor

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

Info Sheet

I088240 Info Sheet PDF

References

Chen L, Chiang Y, Chan L, et al. The CBP/β-catenin antagonist, ICG-001, inhibits tumor metastasis via blocking of the miR-134/ITGB1 axis-mediated cell adhesion in nasopharyngeal carcinoma. Cancers (Basel). 2022 Jun 25;14(13):3125. PMID: 35804897

Yu Y, Mo H, Zhuo H, et al. High fat diet induces kidney injury via stimulation Wnt/β-catenin signaling. Front Med (Lausanne). 2022 Apr 7;9:851618. PMID: 35462998

Brkic F, Stoiber S, Maier T, et al. Targeting Wnt/β-catenin signaling in HPV-positive head and neck squamous cell carcinoma. Pharmaceuticals (Basel). 2022 Mar 20;15(3):378. PMID: 35337176

Roy S, Zhao Y, Yuan Y, et al. Metformin and ICG-001 act synergistically to abrogate cancer stem cells-mediated chemoresistance in colorectal cancer by promoting apoptosis and autophagy. Cancers (Basel). 2022 Mar 2;14(5):1281. PMID: 35267590

Custom Order

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